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Sex differences in the oxygen affinity of hemoglobin

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The oxygen dissociation curves of 50 healthy young nonsmokers 25 women and 25 men, were investigated. The following parameters were deter-mined: hemoglobin concentration, microhematocrit, red cell count, mean corpuscular hemoglobin concentration, capillary blood pH,P 50 value, and the concentration of red cell 2,3-diphosphoglycerate.

P 50 values are significantly higher in the female group (28.3 mm Hg±0.4 S.E.M.) than in the male group (26.3 mm Hg±0.4 S.E.M.), indicating a lower oxygen affinity of hemoglobin in females.

There is no significant difference between the DPG values. No significant negative correlation exists between the Hb concentration and theP 50 values.

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with the technical assistance of Monika Humpeler and Edith Gasser

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Humpeler, E., Amor, H. Sex differences in the oxygen affinity of hemoglobin. Pflugers Arch. 343, 151–156 (1973).

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Key words

  • 2,3-Diphosphoglycerate
  • Sex Differences in the Oxygen Dissociation Curve
  • Oxygen Affinity of Hemoglobin