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Voltage-gated Ca2+ current in pancreatic B-cells

Abstract

Voltage-dependent inward Ba++ and Ca++ currents were recorded in cultured neonatal rat pancreatic islet cells using the whole-cell voltage clamp technique. Outward current was suppressed by internal Cs+ and ATP and external TEA. Inward currents activated rapidly and decayed to a variable extent. The current decay was particularly marked when using long duration or large depolarizing pulses. Currents were due to Ca++ channel activation since they were abolished by omitting Ba++ and Ca++ or including Co++.

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Satin, L.S., Cook, D.L. Voltage-gated Ca2+ current in pancreatic B-cells. Pflugers Arch. 404, 385–387 (1985). https://doi.org/10.1007/BF00585354

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Key Words

  • Ca++ current
  • Ca++ channels
  • pancreatic B-cells