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The role of the sarcoplasmic reticulum in the pure frequency potentiation: The effect of ryanodine

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The dependence of the contraction amplitude of the isolated papillary muscle of the guinea pig on the stimulation pattern is probably caused by a well working sarcoplasmic reticulum. This view is supported by the finding that the alkaloid ryanodine flattens the curve of the force-frequency relationship and abolishes the pure frequency potentiation. Ryanodine is said to destroy exclusively the connection between T-tubulus and sarcoplasmic reticulum.

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  1. Edman, K. A. P. and M. Johannsson: The contractile state of rabbit papillary muscles in relation to stimulation frequency. J. Physiol.254, 565–581 (1976).

  2. Frank, M. and W. W. Sleator jr.: Effects of ryanodine on a myocardial membrane vesicular fractions. Res. Commun. Chem. Path. Pharmacol.11, 65–72 (1975).

  3. Kedem, J., Mahler, Y. and S. Rogel: The effect of heart rate on myocardial contractility during single and paired pulse stimulation “in vivo”. Arch. int. Physiol. Biochem.77, 880–892 (1969).

  4. Nayler, W. G., Daile, P., Chipperfield, D. and K. Gan: Effect of ryanodine on calcium in cardiac muscle. Amer. J. Physiol.219, 1620–1626 (1970).

  5. Penefsky, Z. J. and M. Kahn: Mechanical and electrical effects of ryanodine on mammalian heart muscle. Amer. J. Physiol.218, 1682–1689 (1969).

  6. Penefsky, Z. J.: Studies on mechanism of inhibition of cardiac muscle contractile tension by ryanodine. Mechanical response. Pflügers Arch.247, 173–184 (1974 a).

  7. Penefsky, Z. J.: Ultrastructural studies of the site of action of ryanodine on heart muscle. Pflügers Arch.347, 185–198 (1974 b).

  8. Rumberger, E. and H. Reichel: The force-frequency relationship: A comparative study between warm-and cold-blooded animals. Pflügers Arch.332, 206–217 (1972).

  9. Sleator, W. W. jr, Furchgott, R. F., De Gubareff, T. and V. Krespi: Action potentials of guinea pig atria under conditions which alter contraction. Amer. J. Physiol.206, 270–282 (1964).

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Rumberger, E. The role of the sarcoplasmic reticulum in the pure frequency potentiation: The effect of ryanodine. Pflugers Arch. 364, 203–204 (1976). https://doi.org/10.1007/BF00585192

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Key words

  • Isolated papillary muscle
  • ryanodine
  • force-frequency-relationship
  • pure frequency potentiation