The dependence of the contraction amplitude of the isolated papillary muscle of the guinea pig on the stimulation pattern is probably caused by a well working sarcoplasmic reticulum. This view is supported by the finding that the alkaloid ryanodine flattens the curve of the force-frequency relationship and abolishes the pure frequency potentiation. Ryanodine is said to destroy exclusively the connection between T-tubulus and sarcoplasmic reticulum.
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Rumberger, E. The role of the sarcoplasmic reticulum in the pure frequency potentiation: The effect of ryanodine. Pflugers Arch. 364, 203–204 (1976). https://doi.org/10.1007/BF00585192
- Isolated papillary muscle
- pure frequency potentiation