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Encoding of visceral noxious stimuli in the discharge patterns of visceral afferent fibres from the colon

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Abstract

Afferent fibres, in the inferior splanchnic nerves and lumbar white rami, which supply the colon and its mesentery in the cat, were investigated for their responses to distension and contraction of the colon and to local pressure applied to colon and its mesentery. 1) 63% (177 out of 287) of the axons had resting activity (median 0.3 imp/s). These axons were either unmyelinated (conduction velocity below 2 m/s) or thin myelinated (conduction velocity below 18 m/s). Most axons without resting activity (N=95 out of 106 axons) conducted at less than 1.4 m/s, and most were probably sympathetic efferents. 2) 76 out of 80 afferent units with resting activity (95%) and 8 out of 27 units without (30%) were excited by distension of the colon. The thresholds were largely at intraluminal pressures of around 25 mm Hg or higher. 3) Most afferent units (87%) responded with an increased steady state discharge throughout the distension with or without initial dynamic response. The rest of the afferent units responded only with a transient discharged to distension. 4) Most afferent units reacted in a graded manner to variable intraluminal pressures. 5) In only 43% of the distension-sensitive afferent units could mechanoreceptive sites be located on the wall of the colon or in the mesentery. The majority of the afferent units had one mechanoreceptive site only, some had two. 6) Afferent units reacting to colon distension were also excited by contraction of the colon. 7) The excitability spectrum of visceral afferent fibres in the inferior splanchnic nerves, which are activated by colon distension, suggests that these units are involved in visceral nociception from the colon.

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References

  1. 1.

    Bentley FH, Smithwick RH (1940) Visceral pain produced by balloon distension of the jejunum. Lancet 2:389–391

  2. 2.

    Blumberg H, Haupt P, Jänig W, Kohler W (1980) Response pattern of visceral afferents from the cat's colon upon noxious and nonnoxious stimuli. Pflügers Arch 384:R31

  3. 3.

    Burges PR, Pearl ER (1973) Cutaneous mechanoreceptors and nociceptors. In: Iggo A (ed) Somatosensory system, Handbook of sensory physiology, vol II. Springer, Berlin Heidelberg New York, pp 29–78

  4. 4.

    Cannon B (1933) A method of stimulating autonomic nerves in the unanesthetized cat with observations on the motor and sensory effects. Am J Physiol 105:366–372

  5. 5.

    Casati R, Lombardi F, Malliani A (1979) Afferent sympathetic unmyelinated fibres with left ventricular endings in cats. J Physiol 292:135–148

  6. 6.

    Cervero F (1980) Deep and visceral pain. In: Kosterlitz HW, Terenius LY (eds) Pain and society. Dahlem-Konferenzen. Verlag Chemie, Weinheim pp 263–281

  7. 7.

    Cervero F (1982) Afferent activity evoked by natural stimulation of the biliary system in the ferret. Pain 13:137–151

  8. 8.

    Crousillat J, Ranieri F (1980) Mecanorécepteurs splanchniques de la voie biliaire et de son péritoine. Exp Brain Res 40:146–153

  9. 9.

    Downman CBB, McSwiney BA, Vass CCN (1948) Sensitivity of the small intestine. J Physiol 107:97–106

  10. 10.

    Floyd K, Hick VE, Morrison JFB (1976) Mechanosensitive afferent units in the hypogastric nerve of the cat. J Physiol 259:457–471

  11. 11.

    Floyd K, Morrison JFB (1974) Splanchnic mechanoreceptors in the dog. Quart J Exp Physiol 59:361–366

  12. 12.

    Goldscheider A (1920) Das Schmerzproblem. Springer, Berlin

  13. 13.

    Goldscheider A (1926) Schmerz. In: Bethe A, Bergmann Gv, Embden G, Ellinger A (eds) Handbuch der normalen und pathophysiologischen Physiologie. Band 11. Receptionsorgane I. Springer, Berlin, pp 181–202

  14. 14.

    Handwerker HO, Zimmermann M (1976) Schmerz und vegetatives Nervensystem. In: Sturm A, Birkmayer W (eds) Klinische Pathologie des vegetativen Nervensystems. Band I. Fischer, Stuttgart, pp 468–497

  15. 15.

    Haupt P, Jänig W, Kohler W (1981) How are stimuli which are harmful to the colon and elicit pain in man encoded in the discharge pattern of visceral thoracolumbar afferents. Pain, Suppl 1:88

  16. 16.

    Haupt P, Jänig W, Kohler W (1983) Response pattern of visceral afferent fibres, supplying the colon, upon chemical and mechanical stimuli. Pflügers Arch 398:41–47

  17. 17.

    Hertz AF (1911) The sensibility of the alimentary canal in health and disease. Lectures I–III. Lancet 1:1051–1056, 1119–1124, 1187–1193

  18. 18.

    Kinsella VJ (1940) Sensibility in the abdomen. Br J Surg 27:449–463

  19. 19.

    Leek BF (1972) Abdominal visceral receptors. In: Neil E (ed) Enteroreceptors, Handbook of sensory physiology, vol III/1. Springer, Berlin Heidelberg New York, pp 113–160

  20. 20.

    Liavag J (1967) Acute mesenteric vascular insufficiency. Acta Chir Scand 133:631–639

  21. 21.

    Lim KS (1960) Visceral receptors and visceral pain. Ann NY Acad Sci 86:73–89

  22. 22.

    Lipkin M, Sleisenger MH (1958) Studies of visceral pain: measurements of stimulus intensity and duration associated with the onset of pain in esophagus, ileum and colon. J Clin Invest 37:28–34

  23. 23.

    Lombardi F, Della Bella P, Casati R, Malliani A (1981) Effects of intracoronary administration of bradykinin on the impulse activity of afferent sympathetic unmyelinated fibers with left ventricular endings in the cat. Circ Res 48:69–75

  24. 24.

    Malliani A, Lombardi F (1982) Consideration of the fundamental mechanisms eliciting cardiac pain. Am Heart J 103:575–578

  25. 25.

    Moore RM (1938) Some experimental observations relating to visceral pain. Surg 3:534–555

  26. 26.

    Moore RM, Singleton AO (1933) Studies of pain-sensibility of arteries. II. Peripheral paths of afferent neurones from the arteries of the extremities and of the abdominal viscera. Am J Physiol 104: 267–275

  27. 27.

    Morrison JFB (1977) The afferent innervation of the gastrointestinal tract. In: Brooks FB, Evers PW (eds) Nerves and the gut. Charles B Slack, Inc., Thorofare, NJ, pp 297–322

  28. 28.

    Morrison JFB (1981) Sensory processing in spinal afferent pathways from the bladder. In: Grastyan E, Molnár P (eds) Sensory functions. Adv Physiol Sci, vol 16. Akadémiai Kiado, Budapest; Pergamon Press, Oxford, pp 325–333

  29. 29.

    Polland WS, Bloomfield AL (1931) Experimental referred pain from the gastrointestinal tract. Part II: Stomach, duodenum and colon. J Clin Invest 10:435–473

  30. 30.

    Propping (1909) Zur Frage der Sensibilität der Bauchhöhle. Beitr Klin Chir 63:690–710

  31. 31.

    Ranieri F, Mei N, Crousillat J (1973) Splanchnic afferents arising from gastro-intestinal and peritoneal mechanoreceptors. Exp Brain Res 16:276–290

  32. 32.

    Ritter C (1909) Zur Frage der Sensibilität der Bauchorgane. Zentralbl Chir 35:609–615

  33. 33.

    Sherrington CS (1906) The integrative action of the nervous system. Yale University Press, New Haven, CT

  34. 34.

    Uchida Y, Murao S (1974) Excitation of afferent cardiac sympathetic nerve fibres during coronary occlusion. Am J Physiol 226:1094–1099

  35. 35.

    White JC (1943) Sensory innervation of the viscera. Studies on visceral afferent neurones in man based on neurosurgical procedures for the relief of intractable pain. Res Publ Assoc Res Nerv Ment Dis 23:373–390

  36. 36.

    Woodworth RS, Sherrington CS (1904) A pseudaffective reflex and its spinal path. J Physiol 31:234–243

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Correspondence to W. Jänig.

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Supported by the Dentsche Forschungsgemeinschaft

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Blumberg, H., Haupt, P., Jänig, W. et al. Encoding of visceral noxious stimuli in the discharge patterns of visceral afferent fibres from the colon. Pflügers Arch. 398, 33–40 (1983). https://doi.org/10.1007/BF00584710

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Key words

  • Visceral afferents supplying the colon
  • Inferior splanchnic nerves
  • Response pattern to distension and contraction of the colon
  • Conduction velocities
  • Cat
  • Visceral nociception