Pflügers Archiv

, Volume 409, Issue 6, pp 635–637 | Cite as

The effect of venous blood stream cooling on survival of bacterially infected rabbits

  • L. K. Vaughn
  • W. L. Veale
  • K. E. Cooper
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology Short Communication


The effect of physical cooling on the mortality rate of rabbits infected withPasteurellamultocida was investigated. Rabbits were colled for 48 hours after bacterial injection by passing cold fluid through small hollow metal cuffs which had been surgically implanted around the abdominal vena cavae of rabbits. The average body temperatures of the rabbits during the 24-hour period after the intravenous injection of livePasteurellamultocida was 40.92±0.20°C in control rabbits and 38.98±0.71°C in cooled rabbits. 90% of physically cooled rabbits survived compared with 46% of control rabbits 48 hours after bacterial injection, suggesting that thermoregulatory effector mechanisms involved in cold defense may enhance survival.

Key words

fever rabbits infection temperature regulation Pasteurellamultocida 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Atwood RP, Kass EH (1964) Relationship of body temperature to the lethal action of bacterial endotoxin. J. Clin. Invest. 43: 151–159Google Scholar
  2. 2.
    Banet M (1979) Fever and survival in the rat. The effects of enhancing fever. Pflugers Arch. 381: 35–38Google Scholar
  3. 3.
    Banet M (1981) Fever and survival in the rat. The effect of enhancing the cold defence responses. Experientia 37: 985–986Google Scholar
  4. 4.
    Banet M, Fischer D, Hartman KU, Hensel H, Hilling U (1981) The effect of whole body heat exposure and of cooling the hypothalamus on antibody titre in the rat. Pflugers Arch. 391: 25–27Google Scholar
  5. 5.
    Bernheim HA, Kluger MJ (1976) Fever: Effect of drug-induced antipyresis on survival. Science 193: 237–239Google Scholar
  6. 6.
    Covert JB, Reynolds WW (1977) Survival value of fever in fish. Nature, (London) 267: 43–45Google Scholar
  7. 7.
    Downey JA, Mottram KF, Pickering GW (1964) The location by regional cooling of central temperature receptors in the conscious rabbit. J. Physiol., (London) 170: 415–441Google Scholar
  8. 8.
    Hampton GR, Sharp WV, Andersen GJ (1973) Long term rabbit restraint — a simple method. Lab. Anim. Sci. 23: 590–591Google Scholar
  9. 9.
    Kluger MJ, Ringler DH, Anver MR (1975) Fever and survival. Science 188: 166–168Google Scholar
  10. 10.
    Klugar MJ, Vaughn LK (1978) Fever and survival in rabbits infected withPasteurella multocida. J. Physiol., (London) 282: 243–251Google Scholar
  11. 11.
    Preston E (1973) Central effects of alpha-adrenergic blocking agents on thermoregulation against venous blood stream cooling in unanesthetized rabbits. Can. J. Physiol. Pharmacol. 51: 472–481Google Scholar
  12. 12.
    Reynolds WW, Casterlin ME, Covert JB (1976) Behavioral fever in teleost fishes. Nature, (London) 259: 41–42Google Scholar
  13. 13.
    Vaughn LK, Bernheim HA, Kluger MJ (1974) Fever in the lizardDipsosaurus dorsalis. Nature, (London) 252: 473–474Google Scholar
  14. 14.
    Vaughn LK, Veale WL, Cooper KE (1980) Antipyresis: Its effect on mortality rate of bacterially infected rabbits. Brain Res. Bull. 5: 69–73Google Scholar
  15. 15.
    Vaughn LK, Veale WL, Cooper KE (1980) Fever and survival in a mammal: effects of central antipyresis. In: Cox B, Lomax P, Milton AS, Schonbaum E (eds) Thermoregulatory Mechanisms and their Therapeutic Implications. 4th Int. Symp. on the Pharmacology of Thermoregulation, Oxford, 1979. Karger, Basel, pp 115–119Google Scholar
  16. 16.
    Vaughn LK, Veale WL, Cooper KE (1981) Effects of antipyresis on bacterial numbers in infected rabbits. Brain Res. Bull. 7: 175–180Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • L. K. Vaughn
    • 1
  • W. L. Veale
    • 2
  • K. E. Cooper
    • 2
  1. 1.Department of Basic SciencesMarquette University School of DentistryMilwaukeeUSA
  2. 2.Division of Medical Physiology, Faculty of MedicineThe University of CalgaryCalgaryCanada

Personalised recommendations