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Pflügers Archiv

, Volume 409, Issue 6, pp 635–637 | Cite as

The effect of venous blood stream cooling on survival of bacterially infected rabbits

  • L. K. Vaughn
  • W. L. Veale
  • K. E. Cooper
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology Short Communication

Summary

The effect of physical cooling on the mortality rate of rabbits infected withPasteurellamultocida was investigated. Rabbits were colled for 48 hours after bacterial injection by passing cold fluid through small hollow metal cuffs which had been surgically implanted around the abdominal vena cavae of rabbits. The average body temperatures of the rabbits during the 24-hour period after the intravenous injection of livePasteurellamultocida was 40.92±0.20°C in control rabbits and 38.98±0.71°C in cooled rabbits. 90% of physically cooled rabbits survived compared with 46% of control rabbits 48 hours after bacterial injection, suggesting that thermoregulatory effector mechanisms involved in cold defense may enhance survival.

Key words

fever rabbits infection temperature regulation Pasteurellamultocida 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • L. K. Vaughn
    • 1
  • W. L. Veale
    • 2
  • K. E. Cooper
    • 2
  1. 1.Department of Basic SciencesMarquette University School of DentistryMilwaukeeUSA
  2. 2.Division of Medical Physiology, Faculty of MedicineThe University of CalgaryCalgaryCanada

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