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Vestibular inputs to the fastigial nucleus; evidence of convergence of macular and ampullar inputs

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Abstract

  1. 1.

    Experiments have been undertaken on 11 decerebrate cats to investigate the effects of natural vestibular stimulation on the activity of cerebellar fastigial neurons.

  2. 2.

    From recordings in the rostral portion of the nucleus during sinusoidal lateral (roll) and horizontal (yaw) rotation, distinctive patterns of response were observed.

  3. 3.

    The majority of neurons sensitive to vestibular stimulation showed responses to a single modality of vestibular activation. During lateral tilt some neurones showed positional sensitivity, others gave responses related to the velocity of movement. Other neurones responded in phase with the velocity of movement in the horizontal plane.

  4. 4.

    Aside from these neuronal responses, others provided indications of a convergence of inputs from different sets of vestibular receptors. In particular, several neurons showed a pattern of response that indicated that they received inputs from otolith receptors and ampullar receptors of the vertical canal. At low velocities of movement their response was positional but with increasing velocity the magnitude of the response increased and there was a marked phase shift of the discharge towards head velocity.

  5. 5.

    Neurons responding to horizontal rotation often showed positional responses during lateral tilt. There were also indications of a convergence of ampullar inputs from both vertical and horizontal canals.

  6. 6.

    The neural pathways mediating these responses are discussed in consideration of previous neuroanatomical and neurophysiological data. We consider it likely that several pathways may act to evoke the patterns of response observed, and a role of the cerebellar cortex is indicated.

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References

  1. Anderson, J. H., Blanks, R. H. I., Precht, W.: Response characteristics of semicircular canal and otolith systems in cat. I. Dynamic responses of primary vestibular fibres. Exp. Brain Res.32, 491–507 (1978)

  2. Brodal, A., Hoivik, B.: Site and mode of termination of primary vestibulocerebellar fibres in the cat. An experimental study with silver impregnation methods. Arch. Ital. Biol.102, 1–21 (1964)

  3. Brodal, A., Torvik, A.: Über den Ursprung der sekundaren vestibulocerebellaren Fasern bei der Katze. Eine experimentellanatomische Studie. Arch. Psychiatr. Ges. Neurol.195, 550–567 (1957)

  4. Brooks, C. McC., Eccles, J. C.: Electrical investigation of the monosynaptic pathway through the spinal cord. J. Neurophysiol.10, 251–273 (1947)

  5. Carpenter, M. B.: Experimental anatomical-physiological studies of the vestibular nerve and cerebellar connections. In: Neural mechanisms of the auditory and vestibular systems. (G. L. Rasmussen, W. Windle, eds.), pp. 297–323. Springfield: C. C. Thomas 1960

  6. Carpenter, M. B., Bard, D. S., Alling, F. A.: Anatomical connections between the fastigial nuclei, the labyrinth and the vestibular nuclei in the cat. J. Comp. Neurol.3, 1–25 (1959)

  7. Coulter, J., Mergner, T., Pompeiano, O.: Integration of afferent inputs from neck muscles and macular labyrinthine receptors within the lateral reticular nucleus. Arch. Ital. Biol.115, 332–354 (1977)

  8. Denoth, F., Magherini, P. C., Pompeiano, O., Stanojevic, M.: Responses of Purkinje cells of the cerebellar vermis to neck and macular vestibular inputs. Pflügers Arch.381, 87–98 (1979)

  9. Duensing, F., Schaefer, K. P.: Über die Konvergenz verschiedener labyrintharer Afferenzen auf einzelne Neurone des Vestibulariskerngebietes. Arch. Psychiatr. Nervenkr.199, 345–371 (1959)

  10. Eccles, J. C., Ito, M., Szentágothai, J.: The cerebellum as a neuronal machine. Berlin, Heidelberg, New York: Springer 1967

  11. Eccles, J. C., Sabah, N. H., Tábořikóvá, H.: The pathway responsible for excitation and inhibition of fastigial neurones. Exp. Brain Res.19, 78–99 (1974)

  12. Erway, L. C., Ghelarducci, B., Pompeiano, O., Stanojevic, M.: Risposta dei neuroni cerebellari di Purkinje e fattigiali al tilt sinusoidale. Atti Congr. Soc. ital. Biol. sper., Soc. Ital. Fisiol., Soc. Ital. Nutr. Um., Siena, n. 60 1977

  13. Erway, L. C., Ghelarducci, B., Pompeiano, O., Stanojevic, M.: Responses of cerebellar fastigial neurons to afferent inputs from neck muscles and macular labyrinthine receptors. Arch. Ital. Biol.116, 173–204 (1978)

  14. Estes, M. S., Blanks, R. H. I., Markham, C. H.: Physiologic characteristics of vestibular first-order canal neurons in the cat. I. Response plane determination and resting discharge characteristics. J. Neurophysiol.38, 1232–1249 (1975)

  15. Favilla, M., Ghelarducci, B., Hill, C. D., Spyer, K. M.: The convergence of ampullar and macular inputs onto cerebellar fastigial neurones in the cat. Neurosci. Lett. Suppl. 1, S353 (1978)

  16. Ferin, M., Grigorian, R. A., Strata, P.: Mossy and climbing fibre activation in the cat cerebellum by stimulation of the labyrinth. Exp. Brain Res.12, 1–17 (1971)

  17. Furuya, N., Kawano, K., Shimazu, H.: Functional organization of vestibulo fastigial projection of the horizontal semicircular canal system in the cat. Exp. Brain Res.24, 75–87 (1975)

  18. Gardner, E. P., Fuchs, A. F.: Single unit responses to natural vestibular stimuli and eye movements in deep cerebellar nuclei of the alert rhesus monkey. J. Neurophysiol.38, 627–649 (1975)

  19. Ghelarducci, B.: Responses of the cerebellar fastigial neurones to tilt. Pflügers Arch.344, 195–206 (1973)

  20. Ghelarducci, B., Pompeiano, O., Spyer, K. M.: Activity of precerebellar reticular neurones as a function of head position. Arch. Ital. Biol.112, 98–125 (1974a)

  21. Ghelarducci, B., Pompeiano, O., Spyer, K. M.: Distribution of the neuronal responses to static tilts within the cerebellar fastigial nucleus. Arch. Ital. Biol.112, 126–141 (1974b)

  22. Kimm, J., Hassul, M., Cogdell, B.: Fastigial neuronal responses to sinusoidal horizontal rotation. Exp. Neurol.50, 579–594 (1976)

  23. Lowenstein, D., Saunders, R. D.: Otolith-controlled responses from the first-order neurons of the labyrinth of the bullfrog (Rana catesbiana) to changes in linear acceleration. Proc. R. Soc. Lond. (Biol.)191, 475–505 (1975)

  24. Matsushita, M., Iwahori, N.: Structural organization of the fastigial nucleus. I. dendrites and axonal pathways. Brain Res.25, 597–610 (1971)

  25. Peterson, B. W.: Distribution of neuronal responses to tilting within the vestibular nuclei of the cat. J. Neurophysiol.30, 750–767 (1970)

  26. Precht, W., Llinas, R.: Direct vestibular afferents to cat cerebellar nuclei. Proc. XXIV Int. Congr. Physiol. Sci., Washington, D. C.. VII: n. 1063, p. 35, 1968

  27. Precht, W., Volkind, R., Blanks, R. H. I.: Functional organization of the vestibular input to the anterior and posterior cerebellar vermis of cat. Exp. Brain Res.27, 143–160 (1977)

  28. Schor, R. H.: Responses of cat vestibular neurons to sinusoidal roll tilt. Exp. Brain Res.20, 347–362 (1974)

  29. Shimazu, H., Precht, W.: Tonic and kinetic responses of cat's vestibular neurons to horizontal angular acceleration. J. Neurophysiol.28, 991–1013 (1965)

  30. Spyer, K. M., Ghelarducci, B., Pompeiano, O.: Gravity responses of neurons in the main reticular formation. J. Neurophysiol.37, 705–721 (1974)

  31. Stanojevic, M., Erway, L., Ghelarducci, B., Pompeiano, O., Willis, W., Jr.: A comparison of the response characteristics of the cerebellar fastigial and vermal cortex neurons to sinusoidal stimulation of macular vestibular receptors. Pflügers Arch., in press (1980)

  32. Wilson, V. J., Uchino, Y., Maunz, R. A., Susswein, A., Fukushima, K.: Properties and connections of cat fastigiospinal neurons. Exp. Brain Res.32, 1–17 (1978)

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Favilla, M., Ghelarducci, B., Hill, C.D. et al. Vestibular inputs to the fastigial nucleus; evidence of convergence of macular and ampullar inputs. Pflugers Arch. 384, 193–201 (1980). https://doi.org/10.1007/BF00584553

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Key words

  • Vestibular
  • Cerebellum
  • Macular
  • Ampullar