Antonie van Leeuwenhoek

, Volume 62, Issue 1–2, pp 95–108 | Cite as

The pheromone signal pathway inSaccharomyces cerevisiae

  • James B. Konopka
  • Stanley Fields


Haploid cells of the yeastSaccharomyces cerevisiae normally undergo a budding life cycle, but after binding the appropriate mating pheromone they undergo a different developmental pathway that leads to conjugation. This intercellular communication between the two mating types activates a signal transduction pathway that stimulates the diverse physiological changes required for conjugation, such as induction of cell surface agglutinins, cell division arrest in G1, morphogenesis to form a conjugation tube, and cell fusion. The components of this pathway include a G protein-coupled receptor, several protein kinases, and a pheromone-responsive transcription factor. The molecular mechanisms that transduce the pheromone signal are remarkably similar to the mechanisms of hormone signaling used in multicellular organisms. Thus, the analysis of the pheromone signal pathway in yeast directly contributes to the study of cell growth and development in other eukaryotic organisms.

Key words

cell cycle control G protein hormone signaling mating transcription yeast 


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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • James B. Konopka
    • 1
  • Stanley Fields
    • 1
  1. 1.Department of MicrobiologyState University of New York at Stony BrookStony BrookUSA

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