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Pflügers Archiv

, Volume 384, Issue 2, pp 131–134 | Cite as

Solubility of inert gases in dog blood and skeletal muscle

  • M. Meyer
  • U. Tebbe
  • J. Piiper
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology

Abstract

Solubility of H2, Ar, CH4 and SF6 was determined at 310 K (37°C) in water, in saline (0.154 mol NaCl/l H2O), in plasma and whole blood of dogs, and in homogenates of the dog gastrocnemius muscle. The liquids were equilibrated with pure gases, and the dissolved gases were extracted and measured by gas chromatography as described previously (Meyer, M.: Pflügers Arch. 375, 161–165, 1978). In saline, the solubilities were 4% (SF6) to 15% (Ar) lower than in water. For dog blood the following mean values for the solubility coefficient (in μmol · l−1 · kPa−1) were found: for H2, 6.44; for Ar, 9.94; for CH4, 11.44; for SF6, 2.62. The red cell/plasma and the muscle/blood solubility ratios were near unity for H2, Ar and CH4 (ranging from 0.9 to 1.3); for SF6, however, they were much higher (about 2.1), apparently due to the high solubility of SF6 in hydrophobic substances (lipids).

Key words

Blood Inert gases Partition coefficient Plasma Solubility 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • M. Meyer
    • 1
  • U. Tebbe
    • 1
  • J. Piiper
    • 1
  1. 1.Abteilung PhysiologieMax-Planck-Institut für experimentelle MedizinGöttingenFederal Republic of Germany

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