Pflügers Archiv

, Volume 360, Issue 1, pp 17–23 | Cite as

Conductance fluctuations in ranvier nodes

  • R. J. van den Berg
  • J. de Goede
  • A. A. Verveen
Article

Summary

Voltage fluctuations associated with the sodium system were measured upon elimination of the potassium current in the nodal membrane by internal application of cesium-ions. The intensity of this noise reaches a maximal value at a membrane potential in the vicinity of −40 mV. Here the power spectrum consists of two additive components: a 1/f component and a Lorentzian. The Lorentzian is associated with h-gate kinetics and is consistent with the binary state conduction model. On the basis of this model the sodium-channel conductance is calculated to be2 to 5·10−12S. The analysis is complicated by the existence of an incomplete slow sodium inactivation process.

Key words

Ranvier Node Membrane Noise Channel Conductance 

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • R. J. van den Berg
    • 1
  • J. de Goede
    • 1
  • A. A. Verveen
    • 1
  1. 1.Department of PhysiologyUniversity of LeidenThe Netherlands

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