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Pflügers Archiv

, Volume 392, Issue 3, pp 244–250 | Cite as

Effect of halothane anesthesia on end-tidal\(P_{CO_2 } \) and pattern of respiration in the rat

  • Yasuichiro Fukuda
  • Wolf R. See
  • Yoshiyuki Honda
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology

Abstract

End-tidal\(P_{CO_2 } \)\(\left( {P_{ET_{CO_2 } } } \right)\) and ventilation of the rat anesthetized with halothane were measured. The\(P_{ET_{CO_2 } } \) measured by an infrared analyzer agreed well with the simultaneously measured\(Pa_{CO_2 } \) in the range from 20–60 mm Hg (2.7–8.0 kPa). When the level of anesthesia was deepened by increasing the halothane concentration from 0.9–3.0%, minute ventilation was decreased progressively accompanied by a rise in\(P_{ET_{CO_2 } } \) and the CO2 output was reduced. Halothane induced a progressive decrease in frequency of respiration (f) with almost constant or even slight increase in tidal volume (VT). Decrease inf was caused largely by the prolongation of expiratory duration (TE). Changes in inspiratory duration (TI) were small and the meanVT/TI ratio remained unaltered at different levels of anesthesia. These changes in respiratory pattern induced by halothane anesthesia contrasted with the simultaneous decrease inVT,f andVT/TI ratio and apparent changes of bothTI andTE reported in other species. Species differences in effects of anesthesia on ventilation were discussed. Restraining the rat on a stereotaxic apparatus with head holders, especially with ear bars, elicited an initial transient stimulation of ventilation which was followed by a strong depression.

Key words

Rat End-tidal\(P_{CO_2 } \) Halothane anesthesia Respiratory pattern 

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References

  1. 1.
    Bradley GW (1977) Control of the breathing pattern. In: Widdicombe JG (ed) Respiratory physiology, Vol II. University Park Press, Baltimore, pp 185–217Google Scholar
  2. 2.
    Churchill-Davidson HC (1978) A practice of anaesthesia (5th ed). W.B. Saunders Company, Philadelphia London Toronto, pp 304–324Google Scholar
  3. 3.
    Clark FJ, von Euler C (1972) On the regulation of depth and rate of breathing. J Physiol (Lond) 222:267–295Google Scholar
  4. 4.
    Deutsch S, Linde HW, Dripps RD, Price HL (1962) Circulatory and respiratory actions of halothane in normal man. Anesthesiology 23:631–638Google Scholar
  5. 5.
    France CJ, Plumer MH, Eger EI, Wahrenbrock EA (1974) Ventilatory effects of isoflurare (forare) or halothane when combined with morphine, nitrous oxide and surgery. Br J Anaesth 46:117–120Google Scholar
  6. 6.
    Fukuda Y, Hayashi F, Yoshida A, Honda Y (1980) A quick and quantitative analysis of the CO2-ventilation response of the anesthetized rat by rebreathing method. In: Ito M (ed) Integrative control functions of the brain, Vol III. Kohdansha Scientific, Tokyo, pp 216–218Google Scholar
  7. 7.
    Gautier H (1976) Pattern of breathing during hypoxia or hypercapnia of the awake or anesthetized cat. Respir Physiol 27:193–206Google Scholar
  8. 8.
    Gautier H, Gaudy JH (1978) Changes in ventilatory pattern induced by intravenous anesthetic agents in human subjects. J Appl Physiol 45:171–176Google Scholar
  9. 9.
    Goldberg MS, Milic-Emili J (1977) Effect of pentobarbital sodium on respiratory control in newborn rabbits. J Appl Physiol 42:845–851Google Scholar
  10. 10.
    Hayashi F, Yoshida A, Fukuda Y, Honda Y (1980) Quantitative analysis of CO2-ventilation and-phrenic activity responses of the anesthetized rat with rebreathing method. Proc Int Un Physiol Sci, Vol XIV, p 466Google Scholar
  11. 11.
    Jennett S (1976) Methods of studying the control of breathing in experimental animals and man. Pharmacol Ther B 2:683–716Google Scholar
  12. 12.
    Lai YL, Hildebrandt J (1978) Respiratory mechanics in the anesthetized rat. J Appl Physiol 45:255–260Google Scholar
  13. 13.
    Lai YL, Tsuya Y, Hildebrandt J (1978) Ventilatory responses to acute CO2 exposure in the rat. J Appl Physiol 45:611–618Google Scholar
  14. 14.
    Merkel G, Eger EI (1963) A comparative study of halothane and halopropane anesthesia. Anesthesiology 24:346–357Google Scholar
  15. 15.
    Nishino T, Honda Y (1980) Changes in respiratory pattern induced by halothane in the cat. Br J Anaesth 52:1191–1198Google Scholar
  16. 16.
    Olson EB Jr, Dempsey JA (1978) Rat as a model for humanlike ventilatory adaptation to chronic hypoxia. J Appl Physiol 44:763–769Google Scholar
  17. 17.
    Palecek F (1969) Measurement of ventilatory mechanics in the rat. J Appl Physiol 27:149–156Google Scholar
  18. 18.
    Pappenheimer JR (1977) Sleep and respiration of rats during hypoxia. J Physiol (Lond) 266:191–207Google Scholar
  19. 19.
    Reeve EB, Nanson EM, Rundle FF (1951) Observations on inhibitory respiratory reflexes during abdominal surgery. Clin Sci 10:65–87Google Scholar
  20. 20.
    Severinghaus JW, Cullen SC (1958) Depression of myocardium and body oxygen consumption with fluothane. Anesthesiology 19:165–177Google Scholar
  21. 21.
    Severinghaus JW, Larson CP Jr (1965) Respiration in anesthesia. In: Fenn WO, Rahn H (eds) Handbook of physiology, Sect 3, Respiration, Vol II. Americal Physiological Society, Washington DC, pp. 1219–1264Google Scholar
  22. 22.
    Snedecor GW, Cochran WG (1967) Statistical methods (6th ed.). The Iowa State University Press, AmesGoogle Scholar
  23. 23.
    Widdicombe JC (1964) Respiratory reflexes: In: Fenn WO, Rahn H (eds) Handbook of physiology, Sect 3, Respiration, Vol I. American Physiological Society, Washington DC, pp 585–630Google Scholar
  24. 24.
    Younes M, Youssef M (1978) Effect of five human anesthetics on respiratory control in cats. J Appl Physiol 44:596–606Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Yasuichiro Fukuda
    • 1
  • Wolf R. See
    • 2
  • Yoshiyuki Honda
    • 1
  1. 1.Department of Physiology II, School of MedicineChiba UniversityChibaJapan
  2. 2.Institut für PhysiologieRuhr-Universität BochumBochum 1Germany

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