Virchows Archiv A

, Volume 398, Issue 3, pp 291–304 | Cite as

Renal oncocytoma

A review of the literature and report of an unusual multicentric case
  • Jon D. van der Walt
  • Hugh A. S. Reid
  • R. Anthony Risdon
  • James H. F. Shaw


Renal oncocytoma is a rare tumour of the kidney composed exclusively of large polygonal cells with eosinophilic, granular cytoplasm. Ultrastructurally they are distinguished by the presence of large numbers of mitochondria and histochemically by abundant oxydative enzymes and adenosine triphosphate. Macroscopically these tumours are usually light brown in colour and commonly exhibit a dense central area of fibrous scarring, with fibrous trabeculae extending from this central zone in a stellate fashion. Renal oncocytomas are commoner in males than females (sex ratio 2:1) and although the age range at presentation is wide, there is a peak incidence in the seventh decade. The prognosis following surgical removal is excellent, despite the fact that many of these tumours are large. Invasion of the perirenal fat and the renal vein and metastatic spread to regional lymph nodes is documented, but death from metastatic disease is rare. The great majority of renal oncocytomas reported are solitary. We describe a multicentric renal oncocytoma, the sixth so far reported.

Key words

Renal Neoplasm Oncocytoma Eosinophilic adenoma 


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  1. Akhtar M, Kott E (1979) Oncocytoma of kidney. Urology 14:397–400Google Scholar
  2. Ambos MA, Bosniak MA, Valensi QJ, Madayag MA, Lefleur RS (1978) Angiographic patterns in renal oncocytomas. Radiology 129:615–622Google Scholar
  3. Apitz K (1944) Die Geschwülste und Gewebsmissbildungen der Nierenrinde: Die Adenoma. Virchows Archiv [Pathol Anat] 311:328–359Google Scholar
  4. Bannasch P, Krech R, Zerban H (1978) Morphogenesis and micromorphology of epithelial tumours induced in the rat kidney by nitrosomorpholine: III. Oncocytic tubules and oncocytomas. Z Krebsforsch 92:87–104Google Scholar
  5. Barth KH, Menon M (1980) Renal oncocytoma.Further diagnostic observations. Diag Imaging 49:259–265Google Scholar
  6. Berger G, Clermont A, Pinet F, Loire R (1973) Oncocytome Pluricentrique du rein. Etude micro-angiographique. Arch Anat Pathol 21:287–292Google Scholar
  7. Blessing MH, Wienert G (1973) Onkozytom der Niere. Zbl Allg Pathol 117:227–234Google Scholar
  8. Blessing MH, Burkert E, Lehmann HD (1979) Fibrosarkom in einem onkozytären Adenom der Niere. Urologe A 18:99–101Google Scholar
  9. Bokinsky GB (1981) Renal oncocytoma. Urology 17:364–366Google Scholar
  10. Bonavita JA, Pollack HM, Banner MP (1981) Renal oncocytoma: Further observations and literature review. Urol Radiol 2:229–234Google Scholar
  11. Bondeson L, Bondeson AG, Ljungberg O, Tibblin S (1981) Oxyphil tumours of the thyroid. Ann Surg 194:677–680Google Scholar
  12. Bono AV, Caresano A, Roggia A, Gianneo E (1980) A case of renal oncocytoma, Eur Urol 6:247–248Google Scholar
  13. Chaudhry AP, Satchidanand SK, Gaeta JF, Slotkin E, Shenoy S, Nickerson PA (1979) Light and ultrastructural studies of renal oncocytic adenoma. Urology 14:392–396Google Scholar
  14. Duclos JM, Jardin A, Brisset JM, Kuss R (1975) Les oncocytomes du rein. J Urol Nephrol 81:683–6Google Scholar
  15. Ejeckam G, Tolnai G, Sarkar K, Mc Caughey WTE (1979) Renal oncocytoma. Urology 14:186–189Google Scholar
  16. Eker R, Mossige J, Johannessen JV, Aars H (1981) Hereditary renal adenomas and adenocarcinomas in rats. Diagn Histopathol 4:99–110Google Scholar
  17. Gray SR, Cornog JL, Seo IS (1976) Oncocytic neoplasms of salivary glands. A report of fifteen cases including two malignant oncocytomas. Cancer 38:1306–1317Google Scholar
  18. Hamperl H (1931) Beiträge zur normalen und pathologischen Histologie menschlicher Speicheldürsen. Z Mikrosk Anat Forsch 27:1–55Google Scholar
  19. Hamperl H (1962) Benign and malignant oncocytoma. Cancer 15:1019–1027Google Scholar
  20. Harrison RH, Baird JM, Kowierschke SW (1981) Renal oncocytoma: Ten year follow up. Urology 17:596–599Google Scholar
  21. Jander HP (1979) Letter: Renal oncocytoma; A nonentity. Radiology 130:815–817Google Scholar
  22. Johnson JR, Thurman AE, Metter JB, Bannayan GA (1979) Oncocytoma of the kidney. Urology 14:181–185Google Scholar
  23. Kay S, Armstrong KS (1980) Oncocytic tubular adenoma of the kidney — Report of three cases with 28 year followup on one. In: Fenoglio CM, Wolff M (eds) Progress in surgical pathology, vol 2. Masson Publishing USA, Inc, New York:259–268Google Scholar
  24. Kendall AR, Pollack HM, Petersen RO, Stein BS (1980) Incidentally found renal mass. J Urol 124:269–273Google Scholar
  25. Kini SR, Miller JM, Hamburger JI (1981) Cytopathology of Hürthle cell lesions of the thyroid gland by fine needle aspiration. Acta Cytol 25:647–652Google Scholar
  26. Klein MJ, Valensi QJ (1976) Proximal tubular adenoma of kidney with so-called oncocytic features. Cancer 38:906–914Google Scholar
  27. Landier JF, Desligneres S, Boccon-Gibod L, Steg A (1979) Les oncocytomes du rein. Sem Hop Paris 55:1275–1279Google Scholar
  28. Lautin EM, Gordon PM, Friedman AC, McCormick JF, Fromowitz FB, Goldman MJ, Sugarman LA (1981) Radionuclide imaging and computed tomography in renal oncocytoma. Radiology 138:185–190Google Scholar
  29. Lennox B (1948) Large-cell small-acinar thyroid tumour of Langhans and incidence of related cell groups in human thyroid. J Pathol Bacteriol 60:295–305Google Scholar
  30. Lieber MM, Tomera KM, Farrow GM (1981) Renal oncocytoma. J Urol 125:481–485Google Scholar
  31. Lucas RB, Thackray AC (1978) The mouth and salivary glands. In: Symmers WStC (ed) Systemic pathology. 2nd Ed. Curchill Livingstone, Edinburgh: 959–960Google Scholar
  32. Marek J, Papousek J, Motlik K (1979) “Giant” oncocytic renal adenomas, C s Patol 15:153–159Google Scholar
  33. Milstoc M (1977) Renal oncocytoma: A rare case of renal adenoma. J Urol 118:856–857Google Scholar
  34. Morales A, Wasan S, Bryniak S (1980) Renal oncocytomas: clinical, radiological and histological features. J Urol 123:261–264Google Scholar
  35. Moura ACF, Nascimento AG (1982) Renal oncocytoma: Report of a case with unusual presentation. J Urol 127:311–313Google Scholar
  36. Murphy GP, Mostofi FK (1965) The significance of cytoplasmic granularity in the prognosis of renal cell carcinoma. J Urol 94:48Google Scholar
  37. Oberling C, Riviere M, Haguenau F (1960) Ultrastructure of the clear cells in renal carcinomas and its importance for the demonstration of their renal origin. Nature (London) 186:402–403Google Scholar
  38. Older RA, Cleeve DM, Fetter BF, Jackson DA (1978) Letter: “Spokewheel” Angiographic pattern in renal masses: non specificity. Radiology 128:836Google Scholar
  39. Pearse HD, Houghton DC (1979) Renal oncocytoma. Urology 13:74–77Google Scholar
  40. Poroshin KK, Galyl-Ogly GA (1965) Oncocytic adenomas, Arkh Patol 27:43–49Google Scholar
  41. Riopelle JL (1951) The nature and origin of the so-called true kidney hypernephroma. Cancer 4:789–802Google Scholar
  42. Rodriguez CA, Buskop A, Johnson J, Fromowitz F, Koss LG (1980) Renal oncocytoma. Pre-operative diagnosis by aspiration biopsy, Acta Cytol 24:355–359Google Scholar
  43. Rothenberger K, Kramann B, Steurer G (1978) Onkozytom der Niere. Urologe A 17:91–93Google Scholar
  44. Schmidt M, Taenzer V (1980) Angiographisches Erscheinungsbild seltener Nierentumoren. Onkozytom und benignes Hypernephrom. Fortschr Roentgenstr 132:417–421Google Scholar
  45. Sos TA, Gray GF, Baltaxe HA (1976) The angiographic appearances of benign renal oxyphilic adenoma. Am J Roentgenol 127:717–722Google Scholar
  46. Sternberger LA, Hardy PH, Cucullis JJ, Meyer HG (1970) The unlabelled antibody enzyme method of immunohistochemistry: Preparation and properties of soluble antigen-antibody complex (Horseradish peroxidase — anti-horse radish peroxidase) and its use in the identification of spirochaetes, J Histochem Cytochem 18:315–333Google Scholar
  47. Sun CN, White HJ, Thompson BW (1975) Oncocytoma (Mitochondrioma) of the parotid gland — an electron microscopic study. Arch Pathol 99:208–214Google Scholar
  48. Susman BR, Levin FC, Barland P, Fromowitz F (1981) Vasculitis associated with renal oncocytoma. NY State J Med 81:1501–1503Google Scholar
  49. Tandler B, Hutter RVD, Erlandson RA (1970) Ultrastructure of oncocytomas of the parotid gland. Lab Invest 23:567–580Google Scholar
  50. Tannenbaum M (1971) Ultrastructural Pathology of human renal cell tumors. Pathol Ann 6:249–277Google Scholar
  51. Tollefsen HR, Shah JP, Huvos AG (1975) Hürthle Cell carcinoma of the thyroid. Am J Surg 130:390–394Google Scholar
  52. Tremblay G (1969) The oncocytes. In: Baqusz E, Jasmin G (eds) Methods and achievements in experimental pathology, vol 4, S Karger, Basel:121–140Google Scholar
  53. Warfel KA, Eble JN (1982) Renal oncocytomatosis. J Urol 127:1179–1180Google Scholar
  54. Wasilkowski A, Dabrowski H (1971) Eosinophilic adenoma of the kidney (oncocytoma). Pol Przegl Chir 43:1051–1054Google Scholar
  55. Weedon D, Splatt AJ, Moore AWE (1979) Proximal tubular adenoma of the kidney. Aust NZJ Surg 49:250–252Google Scholar
  56. Weiner SN, Bernstein RG (1977) Renal Oncocytoma: Angiographic features of two cases. Radiology 125:633–635Google Scholar
  57. Wojtowicz J, Karwowski A, Konkiewicz J, Lukaszewski B (1979) Renal oncocytoma. J Comput assist Tomogr 3:124–125Google Scholar
  58. Wolf C, Samarcq B, Petit J, Rebaiz K (1981) Un nouveau cas d'oncocytome du rein. AnnUro 15:241–243Google Scholar
  59. Woodard BH, Tannenbaum SI, Mossler JA (1981) Multicentric renal oncocytoma. J Urol 126:247–248Google Scholar
  60. Yu GSM, Rendler S, Herskowitz A, Molnar JJ (1980) Renal Oncocytoma. Cancer 45:1010–1018Google Scholar
  61. Zippel L (1942) Zur Kenntnis der Onkocyten. Virchows Archiv [Pathol Anat] 308:360–382Google Scholar
  62. Zollinger HU (1966) Niere und ableitende Harnwege. In: Doerr W, Uehlinger E (eds); Pathologische Anatomie, Band 3. Springer, Berlin Heidelberg New York 672–677Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Jon D. van der Walt
    • 1
  • Hugh A. S. Reid
    • 1
  • R. Anthony Risdon
    • 2
  • James H. F. Shaw
    • 3
  1. 1.Department of HistopathologyChase Farm HospitalEnfieldGreat Britain
  2. 2.Department of Morbid AnatomyThe London HospitalLondon E1
  3. 3.Department of SurgeryEnfield District HospitalEnfieldGreat Britain

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