Advertisement

Pflügers Archiv

, Volume 390, Issue 1, pp 44–48 | Cite as

Left atrial distension and intrarenal blood flow distribution in conscious dogs

  • G. Kaczmarczyk
  • V. Unger
  • R. Mohnhaupt
  • H. W. Reinhardt
Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands

Abstract

Measurements were made with radioactive microspheres of the distribution of renal blood flow in conscious dogs during left atrial distension. Urine volume, sodium excretion, mean arterial blood pressure and heart rate increased during the 60 min period of left atrial distension (increase in left atrial pressure by about 1.0 kPa). Total renal blood flow and cardiac output (electromagnetic flowmeters) did not change. The perfusion rates of four renal zones did not change. Striated muscle blood flow (M. psoas) fell markedly. — Stimulation of left atrial receptors in conscious dogs is followed by an increase in renal and skeletal muscle resistance. The diuresis and natriuresis during left atrial distension is not accompanied by a detectable redistribution of renal cortical blood flow.

Key words

Left atrial distension Intrarenal blood flow Microspheres Conscious dogs Muscle blood flow 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Applegate CW, Gutman RA (1976) Renal intracortical blood flow distribution, function and sodium excretion in response to saline loading of anesthetized and unanesthetized dogs. Pflügers Arch 366:125–130Google Scholar
  2. Barger AC (1966) Renal hemodynamic factors in congestive heart failure. Ann NY Acad Sci 139:276–284Google Scholar
  3. DiBona GF (1978) Neural control of renal tubular reabsorption in the dog. Fed Proc 37:1214–1217Google Scholar
  4. Domenech RJ, Hoffmann JIE, Noble MIM, Saunders KB, Henson JR, Subijanto S (1969) Total and regional coronary blood flow measured by radioactive microspheres in conscious and anesthetized dogs. Circ Res 25:581–596Google Scholar
  5. Henry JP, Gauer OH, Reeves JL (1956) Evidence of the atrial location of receptors influencing urine flow. Circ Res 4:85–90Google Scholar
  6. Kaczmarczyk G, Eigenheer F, Gatzka M, Kuhl U, Reinhardt HW (1978) No relation between atrial natriuresis and renal blood flow in conscious dogs. Pflügers Arch 373:49–58Google Scholar
  7. Kaczmarczyk G, Drake AJ, Eisele R, Mohnhaupt R, Noble MIM, Simgen B, Stubbs J, Reinhardt HW (1981) The role of the cardiac nerves in the regulation of sodium excretion in conscious dogs. Pflügers Arch 390 (in press)Google Scholar
  8. Kahl FR, Flint JF, Szidon JP (1974) Influence of left atrial distension on renal vasomotor tone. Am J Physiol 226:240–246Google Scholar
  9. Karim F, Kidd C, Malpus CM, Penna PE (1972) The effects of stimulation of the left atrial receptors on sympathetic efferent nerve activity. J Physiol (London) 227:243–260Google Scholar
  10. Lloyd TC, Friedman JJ (1977) Effect of left atrium-pulmonary vein baroreflex on peripheral vascular beds. Am J Physiol 233:H587-H591Google Scholar
  11. Mason JM, Ledsome JR (1974) Effects of obstruction of the mitral orifice or distension of the pulmonary vein-atrial junctions on renal and hindlimb vascular resistance in the dogs. Circ Res 35:24–32Google Scholar
  12. Millard RM, Baig H, Vatner SF (1977) Cardiovascular effects of radioactive microsphere suspensions and Tween 80 solutions. Am J Physiol 232:H331-H334Google Scholar
  13. Prosnitz EH, DiBona GF (1978) Effect of decreased renal nerve activity on renal tubular sodium reabsorption. Am J Physiol 235:F557-F563Google Scholar
  14. Reinhardt HW (1969) Habilitationsschrift, Universität MünchenGoogle Scholar
  15. Reinhardt HW, Kaczmarczyk G, Eisele R, Arnold B, Eigenheer F, Kuhl U (1977) Left atrial pressure and sodium balance in conscious dogs on a low sodium intake. Pflügers Arch 370:59–66Google Scholar
  16. Reinhardt HW, Eisele R, Kaczmarczyk G, Mohnhaupt R, Oelkers W, Schimmrich B (1980a) The control of sodium excretion by reflexes from the low pressure system independent of adrenal activity. Pflügers Arch 384:171–176Google Scholar
  17. Reinhardt HW, Kaczmarczyk G, Mohnhaupt R, Simgen B (1980b) Atrial natriuresis under the condition of a constant renal perfusion pressure. Experiments in conscious dogs. Pflügers Arch 389:9–15Google Scholar
  18. Rojo-Ortega JM, Granger P, Boucher R, Genest J (1970) Studies on the distribution of the JGI in the renal cortex of dogs and beavers. Nephron 7:61–66Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • G. Kaczmarczyk
    • 1
  • V. Unger
    • 1
  • R. Mohnhaupt
    • 1
  • H. W. Reinhardt
    • 1
  1. 1.Arbeitsgruppe Experimentelle Anästhesie, Klinikum CharlottenburgFreie Universität BerlinBerlin 19

Personalised recommendations