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  • Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands
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Kinetic parameters of calcium metabolism and femur morphometry in rats

I. Influence of sex and age

Abstract

The aim of this study was to establish the influence of age and sex on the kinetic and morphometric parameters of calcium metabolism. Normal values of kinetic parameters were determined in normal adult rats of different ages (4–20 months) and both sexes. Urinary hydrophyline excretion was also assessed and morphometric measurements of the femur were performed.

Kinetic parameters expressed as rate constants showed a lowering of calcium turnover (k T) in the rapidly exchangeable calcium compartment until the age of 12 months and urinary and fecal rate constants (k u andk f ) showed a small increase. Males exhibited a lower calcium turnover (k T) as well as lower urinary and fecal rate constants. Hydroxyproline excretion diminished with age in both sexes. Lower values were recorded in males. Morphometric parameters of femurs showed no bone loss within the examined age. The results show that differences between the sexes exist in the sense of a faster calcium turnover, higher calcium excretion rate constants, higher collagen degradation and higher bone density in adult female rats.

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Abbreviations

P :

rapidly exchanging pool

E :

slowly exchanging pool

V e :

rate of exchange between P and E

V T :

total loss from P in unite time

V 0+ :

rate of accretion to bone

V u :

rate of excretion in urine

V f :

rate of endogenous fecal excretion

R u ] 0 72 :

total activity excreted in urine between zero and 72 h

R f ] 6 54 :

total activity excreted in feces between 6 and 54h

R s :

plasma specific activity

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This work was partially supported by a research grant from the U.S. Department of Agriculture, Beltsville, Maryland.

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Blanuša, M., Bogunović, M. & Matković, V. Kinetic parameters of calcium metabolism and femur morphometry in rats. Pflugers Arch. 375, 233–238 (1978). https://doi.org/10.1007/BF00582435

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Key words

  • Calcium-45 kinetics
  • Hydroxyproline
  • Bone morphometry
  • Age
  • Sex