In a previous study it was observed that prolonged repetitive stimulation (10.s−1) markedly lengthened the time course of the end-plate current. In order to investigate whether this effect could be due to a more dispersed release of the mediator or to a decreased clearance of the mediator from the synaptic cleft, the rise time of the end-plate current and of the miniature end-plate current were analyzed. The results show that presynaptic factors may be involved.
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Ruzzier, F., Di Gregorio, F. & Scuka, M. On the changes of the time course of the end-plate current during repetitive stimulation. Pflugers Arch. 393, 121–122 (1982). https://doi.org/10.1007/BF00582404
- Neuromuscular transmission
- End-plate current