Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

On the changes of the time course of the end-plate current during repetitive stimulation

  • 14 Accesses

  • 6 Citations


In a previous study it was observed that prolonged repetitive stimulation (10.s−1) markedly lengthened the time course of the end-plate current. In order to investigate whether this effect could be due to a more dispersed release of the mediator or to a decreased clearance of the mediator from the synaptic cleft, the rise time of the end-plate current and of the miniature end-plate current were analyzed. The results show that presynaptic factors may be involved.

This is a preview of subscription content, log in to check access.


  1. Banks P, Till R (1975) A correlation between the effects of anti-mitotic drugs on microtubule assemblyin vitro and the inhibition of axonal transport in nor-adrenergic neurones. J Physiol (Lond) 219: 283–294

  2. Cuénod M, Sandri C, Akert K (1972) Enlarged synaptic vesicles in optic nerve terminals induced by intraocular injection of colchicine. Brain Res 39: 285–296

  3. Grafstein B, Forman DS (1980) Intracellular transport in neurones. Physiol Rev 60: 1167–1283

  4. Gray EG (1978) Synaptic vesicles and microtubules in frog motor end-plates. Proc R Soc B 203: 219–227

  5. Ruzzier F, Scuka M (1979) Effect of repetiti stimulation on the frog neuromuscular transmission. Pflügers Arch 382: 127–132

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ruzzier, F., Di Gregorio, F. & Scuka, M. On the changes of the time course of the end-plate current during repetitive stimulation. Pflugers Arch. 393, 121–122 (1982). https://doi.org/10.1007/BF00582404

Download citation

Key words

  • Neuromuscular transmission
  • End-plate current
  • Colchicine