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Inhibition of glucose-6-phosphate dehydrogenase activity by betamethasone and three of its esters with dermatological importance

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Summary

Betamethasone, betamethasone-17-valerate, betamethasone-17-benzoate, and betamethasone-17,21-diproprionate were investigated for their inhibitory action on glucose-6-phosphate dehydrogenase (G-6-PDH) activity (pure enzyme from yeast, enzyme from human skin homogenate). Between these four compounds, marked differences were encountered which could not be attributed to the presence of an esterified or unesterified steroid. According to these data it does not seem to be justified to consider betamethasone esters simply as the transport forms of the topically inactive betamethasone but one must consider the betamethasone esters having biochemical actions of their own.

Zusammenfassung

Die Hemmwirkung von Betamethason, Betamethason-17-valerat, Betamethason-17-benzoat und Betamethason-17,21-diproprionat auf die Glucose-6-phosphat-Dehydrogenase (G-6-PDH) wurde untersucht. Als Quellen für die Enzymaktivität diente frisches Homogenat menschlicher Haut und Reinenzym aus Hefe. Zwischen den Wirkungen der einzelnen Substanzen fanden sich deutliche Unterschiede, wobei jedoch diese Unterschiede nicht darauf zurückgeführt werden konnten, ob ein freies Steroid oder ein Steroidester vorlag. Aufgrund dieser Ergebnisse scheint es nicht berechtigt, Betamethason-Ester einfach als Transportform des bei lokaler Anwendung ansonsten inaktiven Steroids anzusehen. Die angeführten Ester des Betamethasons besitzen eigene biochemische Wirkungen, die sich in quantitativer Hinsicht vom Betamethason unterscheiden.

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Raab, W.P., Gmeiner, B.M. Inhibition of glucose-6-phosphate dehydrogenase activity by betamethasone and three of its esters with dermatological importance. Arch. Derm. Res. 253, 113–118 (1975). https://doi.org/10.1007/BF00582063

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Keywords

  • Public Health
  • Enzyme
  • Ester
  • Steroid
  • Inhibitory Action