Red cell deformability and adaptation in cholesterol-fed guinea pigs
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Summary
The flow of dietary cholesterol-loaded guinea-pig erythrocytes was observed in a glass capillary viscometer at wall shear stresses of 2 and 56 dynes/cm2. The viscosity of a suspension of red cells (H=56 vol%) in a Ringer-albumin solution served as an estimate of the red cell deformation.
It was found that dietary cholesterol did not significantly alter red cell deformability.
The serum of cholesterol-fed animals showed higher sphering properties (possibly due to a higher concentration of lysolecithin) when incubated under the same conditions as the serum from control animals.
When cholesterol-loaded red cells came into contact with the sphering agent lysolecithin, reduced flow properties were exhibited during prolonged contact, whereas erythrocytes from controls adapted to lysolecithin.
Key words
Erythrocyte deformability Red cell lipids Cholesterol LysolecithinPreview
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References
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