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Search for a method of synthesizing 1,9,10-trimethoxy-2,3-methylenedioxy-aporphine. II. Synthesis of baicalidine

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The synthesis of baicalidine has been effected by the intramolecular oxidative cyclization of 1-(3,4-dimethoxybenzyl)-7-methoxy-2-methyl-5,6-methylenedioxy-1,2,3,4-tetrahydroisoquinoline with thallium trifluoroacetate, confirming the structure proposed for it previously as 1,9,10-trimethoxy-2,3-methylenedioxy-aporphine.

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Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 460–464, July–August, 1986.

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Vinogradova, V.I., Yunusov, M.S. Search for a method of synthesizing 1,9,10-trimethoxy-2,3-methylenedioxy-aporphine. II. Synthesis of baicalidine. Chem Nat Compd 22, 430–433 (1986). https://doi.org/10.1007/BF00579817

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  • Alkaloid
  • Baicaline
  • Phosphorus Oxychloride
  • Tetrahydroisoquinoline
  • Methylenedioxy