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A study of mortality and urinary excretion of oxalate in male rats following acute experimental intoxication with diethylene-glycol

Preliminary Report

Abstract

Acute intoxication by diethylene glycol (LD 50) in male rats is associated with a considerable urinary excretion of oxalate, which is significantly decreased by alkalinisation and/or intraperitoneal injection of ethanol with hydration. Mortality during the five days following intoxication is significantly decreased by major hydration only or together with pyridoxine administration, but is cancelled by major hydration together with alkalinisation or intraperitoneal administration of ethanol, plus hydration, with or without alkalinisation. — It might be inferred that diethylene glycol has the same metabolic pathway as ethylene glycol and treatment of acute intoxication by diethylene-glycol should be the same as that of acute poisoning with ethylene glycol.

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Supported by a grant from the scientific Council of the Paris Sud Faculty of Medicine and a grant from the Pechiney-Ugine Kühlmann Corporation

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Durand, A., Auzépy, P., Hébert, J.L. et al. A study of mortality and urinary excretion of oxalate in male rats following acute experimental intoxication with diethylene-glycol. Europ. J. Intensive Care Med 2, 143–146 (1976). https://doi.org/10.1007/BF00579697

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Key words

  • Diethylene glycol
  • Oxaluria
  • Ethanol
  • Antifreeze