Chemistry of Natural Compounds

, Volume 18, Issue 4, pp 375–388 | Cite as

Supercytostatics and supercytotoxins

  • A. A. Semenov
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Abstract

Natural compounds are considered which in concentrations of 5·10−8 M inhibit the proliferation of culturable malignant mammalian cells. It is proposed to call them supercytostatics and supercytotoxins. Their cytotoxic activities are based on various biochemical mechanisms. Among the supercytostatics there are mitotic poisons, inhibitors of protein and nucleic acid synthesis, and membrane and cytoplasmic enzymes. However, in many cases there are grounds for assuming that the critical cell targets do not coincide with the observed biochemical effects of the supercytostatics. In spite of their diverse chemical structures, the majority of substances contain similar structural fragments which may be complementary to unknown receptors participating in the regulation of cell proliferation.

Keywords

Colchicine Taxol Triptolide Dicarbonyl Cucurbitacin 
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© Plenum Publishing Corporation 1983

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  • A. A. Semenov

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