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Chemical modification of the arginine residues of proteins and peptides

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Abstract

Methods for the chemical modification of arginine residues with the aid of butan-2,3-dione and its oligomers, cyclohexane-1,2-dione, phenylglyoxal, tetraethoxy-propane, nitromalondialdehyde, and pentane-2,4-dione are considered. The conditions for performing the reactions and their mechanism are given and the stability of the products formed and methods for their identification are discussed.

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Additional information

Pacific Ocean Institute of Bioorganic Chemistry, Far Eastern Scientific Center, Academy of Sciences of the USSR, Vladivostok. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 591–606, September–October, 1985.

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Makhnyr, V.M. Chemical modification of the arginine residues of proteins and peptides. Chem Nat Compd 21, 553–566 (1985). https://doi.org/10.1007/BF00579052

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Keywords

  • Arginine
  • Borate
  • Dione
  • Ornithine
  • Acetylacetone