Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Influence of alkaline pH on the direct lethal action of miconazole againstCandida albicans

  • 60 Accesses

  • 4 Citations

Abstract

The imidazole group of miconazole is subject to protonation (pKa ∼6.5). Earlier we suggested that the direct lethal action (DLA) of miconazole againstCandida albicans requires nonprotonated drug molecules. DLA declined in intensity as pH was decreased from 6.0. At pH >6.5 most molecules of miconazole exist in the nonprotonated state, but drug also becomes less soluble. Viability studies were designed to assess DLA in relation to alkaline pH. DLA was clearly inhibited with increasing as well as decreasing pH (i.e., pH <6.0 and >7.0), suggesting that nonprotonated neutral drug molecules must be in solution or in extremely small aggregates to elicit DLA, and that the nonprotonated species itself is more soluble at pH 6.0–7.0 than under more alkaline conditions.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Beggs WH. Requirement for nonprotonated drug molecules in the direct lethal action of miconazole againstCandida albicans. Mycopathologia 1988; 103: 91–94.

  2. 2.

    Vanden Bossche H, Willemsens G, Marichal P. Anti-candida drugs: the biochemical basis for their activity. CRC Crit Rev Microbiol 1987; 15; 57–72.

  3. 3.

    Beggs WH. Regulation of the direct fungicidal action of miconazole againstCandida albicans ATCC 26790. Mycoses 1988; 31: 226–228.

  4. 4.

    Beggs WH, Hughes CE. Regulatory function of hydrogen ion on the direct lethal action of miconazole. J Antimicrob Chemother 1987; 20: 450–452.

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Beggs, W.H. Influence of alkaline pH on the direct lethal action of miconazole againstCandida albicans . Mycopathologia 120, 11–13 (1992). https://doi.org/10.1007/BF00578496

Download citation

Key words

  • Antifungal drugs
  • miconazole
  • imidazoles
  • C. albicans