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An early effect of aflatoxin B1 administered in vivo on the growth of bone marrow CFU-GM and the production of some cytokines in rats

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Abstract

Our data demonstrate the granulopoietic toxicity of aflatoxin B1 (AFB1)in vivo and show an impact of this mycotoxin on the production of some humoral regulatory factors dealing with the granulopoietic developmental pathway (CSA, IL-1, IL-2). The dose of AFB1 studied represented approximately 1/5 of LD50 for young male rats. An early suppressive effect of AFB1 towards CFU-GM was transient in treated animals. The peak in granulopoietic activity was preceded in time by an increased CSA and IL-1 formation. Elevated IL-2 synthesis and increased T cell activation paralleled the peak in granulopoietic activity.

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Abbreviations

AFB1 :

Aflatoxin B1

CFU-GM:

granulocyte-monocyte colony-forming unit

CSA:

colony-stimulating activity

CSF:

colony-stimulating factor

GM-CSF:

granulocyte-monocyte CSF

G-CSF:

granulocyte CSF

M-CSF:

monocyte CSF

IL-1–6:

Interleukin 1–6

TNF:

tumour necrosis factor

IFN:

Interferon

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Correspondence to V. Cukrová.

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Cukrová, V., Kurita, N. & Akao, M. An early effect of aflatoxin B1 administered in vivo on the growth of bone marrow CFU-GM and the production of some cytokines in rats. Mycopathologia 120, 113–119 (1992). https://doi.org/10.1007/BF00578296

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Key words

  • Aflatoxin B1
  • colony-stimulating activity
  • granulopoiesis
  • interleukin-1
  • interleukin-2