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Plasma lipids and lipoproteins and essential hypertension

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In recent years there have been many studies demonstrating a correlation between increased arterial blood pressure and altered lipid profiles, and there has been an especially positive correlation between high cholesterol levels and blood pressure. There are differences between the various reports that are important. In our study the lipid distribution in 105 hypertensive patients with mild or moderate arterial hypertension according to WHO criteria without clinically or ultrasonographically apparent atherosclerosis was compared to the lipid distribution in 65 age-matched healthy persons. On the epidemiological level a significant, positive association was found between LDL serum levels (P ≤ 0.001), Apo B serum levels (P ≤ 0.001), serum triglyceride levels (P ≤ 0.05) and VLDL serum levels (P ≤ 0.01) and arterial hypertension. However, in contrast to recent reports, no significant difference was found between total serum cholesterol levels in normotensives and hypertensives, and there was no difference in HDL serum levels. No evidence could be found for a significant increase in lipoprotein (a) serum levels in hypertensives.

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low density lipoprotein


very low density lipoprotein


high density lipoprotein

Apo B 100:

apolipoprotein B 100

Apo A I:

apolipoprotein A I


  1. 1.

    Armstrong VW, Walli AK, Seidel D (1985) Isolation, characterization, and uptake in human fibroblasts of an apo(a)-free lipoprotein obtained on reduction of lipoprotein (a). J Lipid Res 26:1314–1323

  2. 2.

    Berg K, Dahlen G, Frick MG (1974) Lp(a) lipoprotein or pre-beta lipoprotein in patients with coronary heart disease. Clin Genet 6:230–239

  3. 3.

    Berg K, Dahlen G, Borresen A-L (1977) Lp(a) phenotypes, other lipoprotein parameters and family history of heart disease in middle-aged males. Clin Genet 16:347–355

  4. 4.

    Bialecki RA, Tulenko TN (1989) Excess membrane cholesterol alters calcium channel activity in smooth muscle cells of rabbit carotid arteries. Am J Physiol 257: C306-C314

  5. 5.

    Bonaa KP, Thelle DS (1991) Association between blood pressure and serum lipids in a population. Circulation 83:1305–1314

  6. 6.

    Bonaa KH, Bjerve KS, Straume B, et al (1990) Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension: a population based intervention trial from the Tromso study. N Engl J Med 322:795–801

  7. 7.

    Broderick R, Bialecki R, Tulenko TN (1989) Cholesterol-induced changes in rabbit arterial smooth muscle sensitivity to adrenergic stimulation. Am J Physiol 257: H170-H178

  8. 8.

    Bruckert E, Davidoff P, Grimaldi A, et al (1990) Increased serum levels of lipoprotein (a) in diabetes mellitus and their reduction with glycemic control. JAMA 263:325–336

  9. 9.

    Castelli WP, Anderson K (1986) A population at risk. Prevalence of high cholesterol levels in hypertensive patients in the Framingham Study. Am J Med 80 [Suppl 2A]: 23–32

  10. 10.

    Castelli WP, Garrison RJ, Wilson PWF, et al (1986) Incidence of coronary heart disease and lipoprotein cholesterol levels: The Framingham Study. JAMA 256:2835–2838

  11. 11.

    Criqui MH, Barret-Connor E, Holdbrook MJ, et al (1980) Clustering of cardiovascular risk factors. Prev Med 9:525–533

  12. 12.

    Dahlen PN, Guyton JR, Attar M, et al (1986) Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography. Circulation 74:758–765

  13. 13.

    Durrington PN, Ishola M, Hunt L, et al (1988) Apolipoprotein (a), A I, and B and parental history in men with early onset ischaemic heart disease. Lancet 1: 1070–1073

  14. 14.

    Ekelund LG (1988) Lowering lipids and the genesis of hypertension. Drugs 36 [Suppl 3]: 21

  15. 15.

    Ekelund LG, MacMahon RP, Whaley FS, et al (1988) Does lowering of cholesterol with cholestyramine decrease the incidence of hypertension in hypercholesterolemic men? The LRC Coronary Primary Prevention Trial. CVD Epidemiol Newslet 43

  16. 16.

    Fisher-Dzoga K, Wissler RW (1976) Stimulation of proliferation in stationary primary cultures of monkey aortic smooth muscle cells. Part 2. Effect of varying concentrations of hyperlipemic serum and low density lipoproteins of varying dietary fat origins. Atherosclerosis 24:515–521

  17. 17.

    Fless GM, Kirchhausen T, Fisher-Dzoga K, et al (1982) Serum low density lipoproteins with mitogenic effect on cultured aortic smooth muscle cells. Atherosclerosis 41:171–183

  18. 18.

    Fuh MMT, Shieh SM, Wu DA, et al (1987): Abnormalities of carbohydrate and lipid metabolism in patients with hypertension. Arch Intern Med 147:1935–1938

  19. 19.

    Hjermann I, Helgeland A, Home I, et al (1978) The association between blood pressure and serum cholesterol in healthy men: The Oslo study. J Epidemiol Commun Health 32:117–123

  20. 20.

    Hunt SC, Williams RR, Smith JB, et al (1986) Association of three erythrocyte cation transport systems with plasma lipids in Utah subjects. Hypertension 8:30–36

  21. 21.

    Kostner GM, Avogaro P, Cazzolato G, et al (1981) Lipoprotein Lp(a) and the risk for myocardial infarction. Atherosclerosis 38:51–61

  22. 22.

    MacMahon SW, Macdonald GJ, Blacket RB (1985) Plasma lipoprotein levels in treated and untreated hypertensive men and women. The National Heart Foundation of Australia Risk Factor Prevalence Study. Arteriosclerosis 5:391–396

  23. 23.

    Oikawa S, Hori S, Sano R, et al (1987) Effect of low density lipoprotein on DNA synthesis of cultured human arterial smooth muscle cells. Atherosclerosis, 64:7–12

  24. 24.

    Olefsky JM, Farquar JW, Reaven GM (1976) Reappraisal of the role of insulin in hypertriglyceridemia. Am J Med 57:551–560

  25. 25.

    Reaven MR, Hoffmann BB (1989) Hypertension as a disease of carbohydrate and lipoprotein metabolism. Am J Med 87 [Suppl 6A]: 2S-6S

  26. 26.

    Ross R (1986) The pathogenesis of atherosclerosis an update. N Engl J Med 314:488–500

  27. 27.

    Sachinidis A, Locher R, Mengden T, et al (1989) Vasoconstriction: a novel activity for low-density lipoprotein. Biochem Biophys Res Commun 163:315–320

  28. 28.

    Sachinidis A, Mengden T, Locher R, Vetter W (1990) Novel cellular activities for low density lipoprotein in vascular smooth muscle cells. Hypertension 15:704–711

  29. 29.

    Sachinidis A, Locher R, Vetter W (1991) Generation of intracellular signals by low density lipoprotein is independent of the classical LDL receptor. Am J Hypertens 4:274–279

  30. 30.

    Scott-Burden T, Resink T, Hahn AWA, et al (1989) Induction of growth-related metabolism in human vascular smooth muscle cells by low density lipoprotein. J Biol Chem 264:12582–12589

  31. 31.

    Seed M, Hoppichler F, Reaveley D, et al (1990) Relation of serum lipoprotein(a) concentratio and apolipoprotein (a) phenotype to coronary heart disease in patients with familial hypercholesterolemia. N Engl J Med 322:1494–1499

  32. 32.

    Stamler J, Wentworth D, Neaton JD (1986) Is the relationship between serum cholesterol and risk of premature coronary heart disease continuous and graded? Findings in 356 222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA 256:2823–2828

  33. 33.

    Wieland H, Seidel D (1978) Fortschritte in der Analytik des Lipoproteinmusters. Inn Med 7:290–300

  34. 34.

    Williams PT, Fortmann SP, Terry SB, et al (1987) Associations of dietary fat, regional adiposity and blood pressure in men. JAMA 257:3251–3256

  35. 35.

    Williams RR, Hunt SC, Hopkins PN, et al (1988) Familial dyslipidemic hypertension. JAMA 259:3579–3586

  36. 36.

    Wright LC, Sullivan DR, Muller M, et al (1989) Elevated apolipoprotein (a) levels in cancer patients. Int J Cancer 43:241–244

  37. 37.

    Yokohama M, Akita H, Mizutani T, et al (1983) Hyperreactivity of coronary arterial smooth muscles in response to ergonovine from rabbits with hereditary hyperlipidemia. Circ Res 53:63–71

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Correspondence to: H. Vetter

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Flesch, M., Sachinidis, A., Ko, Y.D. et al. Plasma lipids and lipoproteins and essential hypertension. Clin Investig 72, 944–950 (1994). https://doi.org/10.1007/BF00577733

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Key words

  • Hypertension
  • Low density lipoprotein
  • Apo B
  • Cholesterol
  • Very low density lipoprotein
  • Triglycerides
  • Lipoprotein (a)