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Plasma lipids and lipoproteins and essential hypertension

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Abstract

In recent years there have been many studies demonstrating a correlation between increased arterial blood pressure and altered lipid profiles, and there has been an especially positive correlation between high cholesterol levels and blood pressure. There are differences between the various reports that are important. In our study the lipid distribution in 105 hypertensive patients with mild or moderate arterial hypertension according to WHO criteria without clinically or ultrasonographically apparent atherosclerosis was compared to the lipid distribution in 65 age-matched healthy persons. On the epidemiological level a significant, positive association was found between LDL serum levels (P ≤ 0.001), Apo B serum levels (P ≤ 0.001), serum triglyceride levels (P ≤ 0.05) and VLDL serum levels (P ≤ 0.01) and arterial hypertension. However, in contrast to recent reports, no significant difference was found between total serum cholesterol levels in normotensives and hypertensives, and there was no difference in HDL serum levels. No evidence could be found for a significant increase in lipoprotein (a) serum levels in hypertensives.

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Abbreviations

LDL:

low density lipoprotein

VLDL:

very low density lipoprotein

HDL:

high density lipoprotein

Apo B 100:

apolipoprotein B 100

Apo A I:

apolipoprotein A I

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Correspondence to: H. Vetter

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Flesch, M., Sachinidis, A., Ko, Y.D. et al. Plasma lipids and lipoproteins and essential hypertension. Clin Investig 72, 944–950 (1994). https://doi.org/10.1007/BF00577733

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Key words

  • Hypertension
  • Low density lipoprotein
  • Apo B
  • Cholesterol
  • Very low density lipoprotein
  • Triglycerides
  • Lipoprotein (a)