Acta Diabetologica

, Volume 32, Issue 4, pp 251–256 | Cite as

Apolipoprotein AI-CIII-AIV genetic polymorphisms and coronary heart disease in type 2 diabetes mellitus

  • L. Rigoli
  • G. Raimondo
  • A. Di Benedetto
  • G. Romano
  • A. Porcellini
  • S. Campo
  • F. Corica
  • G. Riccardi
  • G. Squadrito
  • D. Cucinotta
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Accepted:

Abstract

The aim of this study was to verify whether or not the increased prevalence of coronary heart disease (CHD) commonly observed in patients with type 2 diabetes mellitus is related to a genetic background involving restriction fragment length polymorphisms (RFLPs) of apolipoproteins. On the basis of a case-control design, 62 type 2 diabetic patients with CHD (confirmed by clinical history and electrocardiogram) and 62 age- and sexmatched diabetic subjects without CHD were enrolled. In each of them RFLPs of the apolipoprotein CIII gene (S1 or S2 allele) and AI promoter region (A or G allele), together with fasting plasma lipids and apolipoproteins levels, were assessed. The rare S2 allele was found significantly (P=0.05) more frequently in patients with CHD, and its related S1S2 genotype was associated with higher plasma levels of total cholesterol (P=0.01), triglycerides (P=0.007) and apo B (P=0.001) than the S1S1 genotype. The A allele was more frequent (P=0.004) in patients without CHD and was associated with lower plasma cholesterol (P=0.0001), low-density lipoprotein (LDL)-cholesterol (P=0.0001) and apo B (P=0.005). The S1/A haplotype was more frequent (P=0.05) in patients without CHD and was associated with the lowest plasma lipid levels. These results suggest that genetic factors, related to the apo AI-CIII-AIV gene cluster, could play a role in the development of CHD in type 2 diabetic patients, probably through modification of their plasma lipid pattern.

Key words

Apolipoprotein gene Restriction fragment length polymorphism Non-insulin-dependent diabetes mellitus Coronary heart disease 
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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • L. Rigoli
    • 1
  • G. Raimondo
    • 1
  • A. Di Benedetto
    • 1
  • G. Romano
    • 1
  • A. Porcellini
    • 2
  • S. Campo
    • 1
  • F. Corica
    • 2
  • G. Riccardi
    • 3
  • G. Squadrito
    • 1
  • D. Cucinotta
    • 1
  1. 1.Department of Internal MedicineUniversity of MessinaMessinaItaly
  2. 2.Department of Cellular and Molecular BiologyUniversity of NaplesNaplesItaly
  3. 3.Institute of Internal Medicine and Metabolic DiseasesUniversity of NaplesNaplesItaly

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