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Synthesis of analogs of natural isoflavones from 2,4-dihydroxydeoxybenzoins

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Abstract

A number of analogs of natural isoflavones have been synthesized. The starting materials were 2,4-dihydroxydeoxybenzoins obtained under modified conditions of the Houben-Hoesch reaction. The yields of the isoflavones synthesized were 63–69%. All the analogs of natural flavones possess a pronounced hypolipidemic action.

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Literature cited

  1. 1.

    G. N. Dorofeenko, A. L. Shinkarenko, A. L. Kazakov, A. I. Pyshchev, and V. V. Mezheritskii, Khim. Prir. Soedin., 160 (1974).

  2. 2.

    A. L. Kazakov, Khim.-Farm. Zh., No. 1, 58 (1979).

  3. 3.

    A. L. Kazakov and S. F. Dzhumyrko, Rast. Res., No. 3, 344 (1979).

  4. 4.

    M. S. Luk'yanchikov, Khim. Prir. Soedin., 43 (1984).

  5. 5.

    A. L. Kazakov and N. I. Kokovkii-Shcherbak, “The prediction of the biological activities of isoflavones as functions of their structures with the aid of an additive model,” in: Abstracts of Lectures at the IIIrd All-Union Congress of Pharmacists of the USSR [in Russian], Kishinev (1980).

  6. 6.

    P. E. Spoerri and A. S. DuBois, Organic Reactions, Coll. Vol.5, 387–412 (1949).

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Additional information

Pyatigorsk Pharmaceutical Institute. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 781–784, November–December, 1985.

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Luk'yanchikov, M.S., Khilya, V.P. & Kazakov, A.L. Synthesis of analogs of natural isoflavones from 2,4-dihydroxydeoxybenzoins. Chem Nat Compd 21, 740–743 (1985). https://doi.org/10.1007/BF00576209

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Keywords

  • Isoflavones
  • Benzoin
  • Formononetin
  • Trifluoroacetic Anhydride
  • Phenylacetonitrile