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Synthesis of analogs of natural isoflavones from 2,4-dihydroxydeoxybenzoins

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A number of analogs of natural isoflavones have been synthesized. The starting materials were 2,4-dihydroxydeoxybenzoins obtained under modified conditions of the Houben-Hoesch reaction. The yields of the isoflavones synthesized were 63–69%. All the analogs of natural flavones possess a pronounced hypolipidemic action.

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Pyatigorsk Pharmaceutical Institute. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 781–784, November–December, 1985.

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Luk'yanchikov, M.S., Khilya, V.P. & Kazakov, A.L. Synthesis of analogs of natural isoflavones from 2,4-dihydroxydeoxybenzoins. Chem Nat Compd 21, 740–743 (1985). https://doi.org/10.1007/BF00576209

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  • Isoflavones
  • Benzoin
  • Formononetin
  • Trifluoroacetic Anhydride
  • Phenylacetonitrile