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DNA-cellulose — A new affinity sorbent for human leucocytic interferon

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Abstract

The possibility has been studied of using affinity chromatography on DNA-cellulose for the purification of interferon. It has been shown that interferon at a low ionic strength binds to DNA-cellulose, and on this basis a new method is proposed for purifying interferon which permits its 200-fold purification with small losses.

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Additional information

Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 766–768, November–December, 1983.

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Mavlanov, G.T., Auelbekov, S.A., Dzhumaev, D.B. et al. DNA-cellulose — A new affinity sorbent for human leucocytic interferon. Chem Nat Compd 19, 727–729 (1983). https://doi.org/10.1007/BF00575180

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Keywords

  • Interferon
  • Affinity Chromatography
  • Newcastle Disease
  • KSCN
  • Linear NaCI Gradient