Our two patients with lysinuric protein intolerance, a 14-year-old boy and his 12-year-old sister, showed growth retardation and their bone ages were retarded. Growth hormone secretion responded to glucagon-propranolol and showed a good response to arginine. However, growth hormone showed little response to insulin. After the oral administration of arginine hydrochloride, growth hormone showed a good response to insulin and glucagon-propranolol, and gain in height and weight accelerated. This result may suggest that an adequate supply of arginine is effective in improving the growth retardation in lysinuric protein intolerance.
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Goto, I., Yoshimura, T. & Kuroiwa, Y. Growth hormone studies in lysinuric protein intolerance. Eur J Pediatr 141, 240–242 (1984). https://doi.org/10.1007/BF00572769
- Lysinuric protein intolerance
- Growth hormone