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Adenyl-cyclase activity in rat-hair-cycle

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In the skin of rat, during telogen phase, a high adenyl-cyclase activity coincides with maximal catecholamines content, minimal histamine level and blocking of mitoses in epithelial cells. These events suggest that in telogen the control of mitotic activity in rat hair follicles may operate through a block of G1 cells as already suggested for epidermal cells.


Während des Stadiums von Telogen fällt in der Haut der Ratte eine hohe Aktivität von “Adenyl-Cyclase” mit einer hohen Konzentration von “Katecholaminen”, einer geringen Konzentration von “Histamin” und eine Hemmung der Mitose von Epithelzellen zusammen.

Diese Daten lassen die Annahme zu, daß während des Telogens die Kontrolle der Zellmitose in Haarfollikel durch eine Hemmung der G1-Phase vor sich geht. Ein entsprechender Mechanismus dürfte auch an epidermalen Zellen zu vermuten sein.

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Cipriani, C., Moretti, G., Rampini, E. et al. Adenyl-cyclase activity in rat-hair-cycle. Arch. Derm. Res. 256, 319–325 (1976).

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  • Public Health
  • Epithelial Cell
  • Histamin
  • Catecholamine
  • Epidermal Cell