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Systemic influence of intravesical chemotherapy with verapamil

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Summary

The influence of the calcium blocker verapamil (VR) on systemic toxicity resulting from the intravesical instillation of Adriamycin (ADM) and thiotepa (THT) was assessed in mice. Eighty per cent of the animals receiving THT+VR developed a generalized alopecia. Data gathered at necroscopy failed to reveal any trauma to the major organs or the presence of a drug-induced myelosuppression. Combination of ADM and VR did not produce and enhancement of systemic toxicity, manifest as myelosuppression. The drug combination did not produce a cardiomyopathy as assessed by histologic examination. The use of VR in combination with antineoplastic agents posed no more of a threat to the animals than did the use of cytotoxin alone.

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References

  1. 1.

    Abbasian A, Wallace D (1966) Intracavity chemotherapy of diffuse non-infiltrating papillary carcinoma of the bladder. J Urol 96:461–465

  2. 2.

    Bruce E, Edgcomb J (1967) Pancytopenia and generalized sepsis following treatment of cancer with instillations of triethylene thiophosphoramide. J Urol 97:482–485

  3. 3.

    Fleckenstein A (1971) Specific inhibitors and promoters of calcium action in the excitation-contraction coupling of heart muscle and their role in prevention or production of moycardial lesions. Calcium and the heart. Acaemic Press, London, p 135–188

  4. 4.

    Gonzalez R, Scheinman M (1981) Treatment of supraventricular arrhythmias with intravenous and oral verapamil. Chest 80:465–470

  5. 5.

    Gottdiener J, Mathisen D, Borer J, Bonow R, Myers C, Barr L, Schartz D, Bacharach S, Green M, Rosenberg S (1981) Doxorubicin cardiotoxicity: assessment of late left ventricular dysfunction by radionuclide cineangiography. Ann Int Med 94:430–435

  6. 6.

    Lefrak E, Pitha J, Rosenheim S, Gottlieb J (1973) A clinicopathologic analysis of adriamycin caridotoxicity. Cancer 32: 302–314

  7. 7.

    Maluf N (1953) Absorption of water, urea, glucose and electrolytes through the human bladder. J Urol 69:396–404

  8. 8.

    Mehta J, Pepine C, Day M, Guerrero J, Conti C (1981) Short-term efficacy of oral verapamil in rest angina: a double-blind placebo controlled trial in CCU patients. Am J Med 71:977–982

  9. 9.

    Mettler F, Young D, Ward J (1977) Adriamycininduced cardiotoxicity (cardiomyopathy and congestive heart failure) in rats. Cancer Res 37:2705–2713

  10. 10.

    Olson H, Young D, Prieur D, LeRoy A, Reagen R (1974) Electrolyte and morphologic alterations of mycocardium in adriamycin-treated rabbits. Am J Pathol 77:439–454

  11. 11.

    Pavone-Macaluso M, Gebbia N, Biondo F, Bertolini S, Caramia G, Rizzo F (1976) Permeability of the bladder mucosa to thiotepa, adriamycin, and daunomycin in men and rabbits. Urol Res 4:9–13

  12. 12.

    Simpson W, Tseng M, Anderson K, Harty J (1984) Verapamil enhancement of chemotherapeutic efficacy in human bladder cancer cells. J Urol (In press)

  13. 13.

    Slater L, Murray S, Wetzel M, Wisdom R, DuVall E (1982) Verapamill restoration of danorubicin responsiveness in danorubicin-resistant ehrlich ascites carcinoma. J Clin Invest 70:1131–1134

  14. 14.

    Tsuruo T, Iida H, Tsukagoshi S, Sakarai Y (1981) Overcoming vincristine resistance in P388 leukemia in vivo and in vitro through enhancement of cytotoxicity of vincristine and vinblastine and vinblastine by verapamil. Cancer Res 41:1967–1972

  15. 15.

    Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y (1982) Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incurbation with calcium antagonists and calmodulin inhibitors. Cancer Res 42:4730–4733

  16. 16.

    Weinstein S, Schmidt J (1976) Doxorubicin chemotherapy in advanced transitional cell carcinoma. Urology 8:336–341

  17. 17.

    Yagoda A, Watson R, Whitmore W, Grabstald H, Middleman M, Krakoff I (1977) Adriamycin in advanced urinary tract cancer. Cancer 39:279–285

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Simpson, W.G., Tseng, M.T. & Harty, J.I. Systemic influence of intravesical chemotherapy with verapamil. Urol. Res. 13, 23–26 (1985). https://doi.org/10.1007/BF00571752

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Key words

  • Verapamil
  • Thiotepa
  • Adriamycin
  • Intravesteal toxicity