Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Effect of diazepam on food consumption in rats

  • 28 Accesses


Diazepam significantly increased milk consumption in rats that had never been exposed to this food before but not in rats trained to drink milk. Diazepam failed to increase lever-pressing for food reward except when this behavior had been previously suppressed by the simultaneous administration of electric shock. These data suggest that diazepam does not alter appetite, but enhances the expression of motivation suppressed by instinct or training.

This is a preview of subscription content, log in to check access.


  1. Barnett, S. A.: Experiments on “neophobia” in wild and laboratory rats. Br. J. Phychol.49, 195–201 (1958)

  2. Fratta, W., Mereu, G., Chessa, P., Paglietti, E., Gessa, G.: Benzodiazepine-induced voraciousness in cats and inhibition of amphetamine-anorexia. Life Sci.18, 1157–1166 (1976)

  3. Geller, I., Seifter, J.: The effect of meprobamate, barbiturates,d-amphetamine and promazine on experimentally induced conflict in the rat. Psychopharmacologia (Berl.)1, 482–492 (1960)

  4. Kirk, R. E.: Experimental design: procedures for the behavioral sciences. Belmont, Calif.: Brooke-Cole 1968

  5. Poschel, B. P. H.: A simple and specific screen for benzodiazepinelike drugs. Psychopharmacologia (Berl.)19, 193–198 (1971)

  6. Soubrié, P., Kulkarni, S., Simon, P., Boissier, J. R.: Effets des anxiolytiques sur la prise de nourriture de rats et de souris placés en situation nouvelle ou familière. Psychopharmacologia (Berl.)45, 203–210 (1975)

  7. Tye, N. C., Nicholas, D. J., Morgan, M. J.: Chlordiazepoxide and preference for free food in rats. Pharmacol. Biochem. Behav.3, 1149–1151 (1975)

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Johnson, D.N. Effect of diazepam on food consumption in rats. Psychopharmacology 56, 111–112 (1978).

Download citation

Key words

  • Diazepam
  • Food consumption
  • Neophobia
  • Disinhibition