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Bone mineral density in hyperandrogenic amenorrhoea

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The authors assessed bone mineral density in antrogenized amenorrheic (group A; n=9_ and androgenized nonamenorrheic patients (group B; n=30) and compared it with controls (n=22). Bone mineral density of group A patients (1.023±0.045 g/cm2) did not differ from controls 1.047±0.83 g/cm2); both groups had significantly lower values than group B women (1.099±0.085 g/cm2). Of the hormonal variables explaining bone mineral density in antrogenized women, only dehydroepiandrosterone sulfate had a significant negative correlation (r=-0.45). In contrast to other forms of amenorrhea, women with hyperantrogenic amenorrhea seem to be spared from osteopenia.

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  1. 1.

    Klibanski A, Neer RM, Beitins IZ, Ridgway EC, Zervas NT, McArthur JW (1980) Decreased bone density in hyperprolactinemic women. N Engl J Med 303:1511–1514

  2. 2.

    Schlechte J, El-Khoury G, Kathol M, Walkner L (1987) Forearm and vertebral bone mineral in treated and untreated hyperprolactinemic amenorrhoea. J Clin Endocrinol Metab 64:1021–1026

  3. 3.

    Rigotti NA, Nussbaum SR, Herzog DB, Neer RM (1984) Osteoporosis in women with anorexia nervosa. N Engl J Med 311: 1601–1606

  4. 4.

    Biller BMK, Saxe V, Herzog DB, Rosenthal D, Holzman S, Klibanski A (1989) Mechanisms of osteoporosis in adult and adolescent women with anorexia nervosa. J Clin Endocrinol Metab 68:548–554

  5. 5.

    Drinkwater BL, Nilson K, Chestnut CH, Bremmer WJ, Shainholtz S, Southworth MB (1984) Bone mineral content of amenorrheic and eumenorrheic athletes. N Engl J Med 311:277–281

  6. 6.

    Lindberg JS, Fears WB, Hunt MM, Powell MR, Boll D, Wade CE (1984) Exercise-induced amenorrhea and bone density. Ann Intern Med 101:647–648

  7. 7.

    Klibanski A, Biller BMK, Rosenthal DI, Schoenfeld DA, Saxe V (1988) Effects of prolactin and estrogen deficiency in amenorrheic bone loss. J Clin Endocrinol Metab 67:124–130

  8. 8.

    Moltz L, Trapp M, Bispink G, Leidenberger F (1987) Rationelle hormonale Diagnostik der sekundaren Amenorrho. Geburtsh u Frauenheilk 47:228–239

  9. 9.

    Hull MGR (1987) Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies. Gynecol Endocrinol 1:235–245

  10. 10.

    Adams J, Polson DW, Franks S (1986) Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br Med J 293:355–359

  11. 11.

    Fox R, Corrigan E, Thomas PG, Hull MGR (1991) Oestrogen and androgen states in oligo-amenorrhoeic women with polycystic ovaries. Br J Obstet Gynecol 98:294–299

  12. 12.

    Dhuper S, Warren MP, Brooks-Gunn J, Fox R (1990) Effects of hormonal status on bone density in adolescent girls. J Clin Endocrinol Metab 71:1083–1088

  13. 13.

    Prior JC, Vigna YM, Schechter MT, Burgess AE (1990) Spinal bone loss and ovulatory disturbances. N Engl J Med 323:1221–1227

  14. 14.

    Orwoll ES, Stribrska L, Ramsey E, Keenan EJ (1991) Androgen receptors in osteoblast-like cell lines. Calcif Tissue Int 49:183–187

  15. 15.

    Finkelstein JS, Klibanski A, Neer RM, Greenspan SL, Rosenthal DI, Croeley WF (1987) Osteoporosis in men with idiopathic hypogonadism. Ann Intern Med 106:354–361

  16. 16.

    Francis RM, Peacock M, Aaron JE, Selby PL, Taylor GA, Thompson J, Marshall DH, Horsman A (1986) Osteoporosis in hypogonadal men: role of decreased plasma 1,25-dihydroxyvitamin D, calcium malabsorption, and low bone formation. Bone 7:261–268

  17. 17.

    Steinberg KK, Freni-Titulaer LW, DePuey EG, Miller DT, Sgoutas DS, Coralli CH, Phillips DL, Rogers TN, Clark RV (1989) Sex steroids and bone density in premenopausal and perimenopausal women. J Clin Endocrinol Metab 69:533–539

  18. 18.

    Buchanan JR, Hospodar P, Myers C, Leuenberger P, Demers M (1988) Effect of excess endogenous androgens on bone density in young women. J Clin Endocrinol Metab 67:937–943

  19. 19.

    Raisz LG (1988) Local and systemic factors in the pathogenesis of osteoporosis. N Engl J Med 318:818–828

  20. 20.

    Pasquali R, Venturoli S, Parasisi R, Capelli M, Parenti M, Melchionda N (1982) Insulin and C-peptide levels in obese patients with polycystic ovarian disease. Horm Metab Res 14:284–287

  21. 21.

    Barbieri RL, Ryan KJ (1983) Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common endocrinopathy with distinct pathophysiologic features. Am J Obstet Gynecol 147:90–101

  22. 22.

    Chang RJ, Nakamura RM, Judd HL, Kaplan SA (1983) Insulin resistance in non-obese patients with polycystic ovarian disease. J Clin Endocrinol Metab 57:356–359

  23. 23.

    Barbieri RL, Smith S, Ryan KJ (1988) The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism. Fertil Steril 50:197–212

  24. 24.

    Dunaif A, Segal KR, Futterweit W, Dobrnjanski A (1989) Profound peripheral insulin resistance, independent of obesity, in polycystic ovarian disease. Diabetes 38:1165–1174

  25. 25.

    Kream BE, Smith MD, Canalis E, Raisz LG (1985) Characterization of the effect of insulin on collagen synthesis in fetal rat bone. Endocrinology 116:296–302

  26. 26.

    Levy JR, Murray E, Manolagas S, Olefsky JM (1986) Demonstration of insulin receptors and modulation of alkaline phosphatase activity by insulin in rat osteoblastic cells. Endocrinology 119:1786–1792

  27. 27.

    Nestler JE, Clore NJ, Strauss JF, Blackard WG (1987) The effect of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in women with hyperandrogenism, insulin resistance, nad acanthosis nigricans. J Clin Endocrinol Metab 64: 180–185

  28. 28.

    Nestler JE, Usiskin KS, Barlascini CO, Welty DF, Clore JN, Blackard WG (1989) Suppression of serum dehydroepiandrosterone sulfate levels by insulin: an evaluation of possible mechanisms. J Clin Endocrinol Metab 69:1040–1046

  29. 29.

    Farah MJ, Givens JR, Kitabchi AE (1990) Bimodal correlation between the circulating insulin level and production rate of dehydroepiandrosterone: positive correlation in controls and negative correlation in the polycystic ovary syndrome with acanthosis nigricans. J Clin Endocrinol Metab 70:1075–1081

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Preželj, J., Kocijančič, A. Bone mineral density in hyperandrogenic amenorrhoea. Calcif Tissue Int 52, 422–424 (1993). https://doi.org/10.1007/BF00571330

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Key words

  • Bone mineral density
  • Hyperandrogenemia
  • Amenorrhea