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Archives of Toxicology

, Volume 35, Issue 4, pp 275–280 | Cite as

Efficacy of repeated pharmacotherapy in experimental acute poisonings with fluostigmine

  • S. Rump
  • J. Faff
  • T. Szymańska
  • W. Bąk
  • G. Borkowska
Original Investigations

Summary

The effectiveness of repeated pharmacotherapy in acute poisonings with fluostigmine was studied in rats. It was demonstrated, that the second i.p. administration of obidoxime (40 mg/kg) was without effect. Repeated i.p. administration of atropine (10 mg/kg) shown marked efficacy only in animals treated previously with atropine (10 mg/kg) and diazepam (2.5 mg/kg). This procedure was without effect in animals treated just after intoxication with atropine (10 mg/kg) or atropine (10 mg/kg) and obidoxime (40 mg/kg). Subsequent administration of diazepam (2.5 mg/kg) or caramiphen (10 mg/kg) was without effect.

Key words

Atropine Caramiphen Diazepam Fluostigmine Obidoxime Organophosphate poisoning 

Zusammenfassung

Es wurde die Wirksamkeit einer wiederholten Zufuhr verschiedener Antidote bei der akuten Vergiftung mit Fluostigmin an Ratten geprüft. Es zeigte sich, daß die zweite i.p. Injektion von Obidoxim (40 mg/kg) keinen zusätzlichen Effekt besitzt. Wiederholte Atropingaben sind nur dann effektiv, wenn die Erstbehandlung mit Atropin (10 mg/kg) und Diazepam (2,5 mg/kg) erfolgte, nicht aber, wenn die Erstbehandlung mit Atropin (10 mg/kg) allein oder Atropin (10 mg/kg) und Obidoxim (40 mg/kg) durchgeführt wurde. Wiederholte Injektionen von Diazepam (1,5 mg/kg) oder Caramiphen (10 mg/kg) brachten keinen Nutzen.

Schlüsselwörter

Atropin Caramiphen Diazepam Fluostigmin Obidoxim Organophosphatvergiftung 

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References

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • S. Rump
    • 1
  • J. Faff
    • 1
  • T. Szymańska
    • 1
  • W. Bąk
    • 1
  • G. Borkowska
    • 1
  1. 1.Department of ToxicologyMilitary Institute of Hygiene and EpidemiologyWarsawPoland

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