Advertisement

Archives of Toxicology

, Volume 62, Issue 2–3, pp 242–245 | Cite as

Nephrotoxicity of orellanine, a toxin from the mushroomCortinarius orellanus

  • Jean-Michel Richard
  • Josette Louis
  • Danielle Cantin
Short Communication

Abstract

Pure orellanine extracted from the mushroomCortinarius orellanus is highly toxic in mice both when given intraperitoneally (LD50=12.5 mg/kg) or per os (LD50 =90 mg/kg). The kidneys of mice injected i.p. with orellanine show similar tubular necrosis to that obtained with whole mushroom given per os. This demonstrates that orellanine is the true, principal toxin ofC. orellanus. The similarity of the structures of the toxin and of bipyridinium herbicides such as methylviologen (paraquat) or the nephrotoxic diquat led other authors to presume a similar mechanism for orellanine toxicity. Our study of the electrochemical behaviour of orellanine shows that its mechanism of action has to be different from that of these poisons.

Key words

Orellanine Cortinarius orellanus Mushroom poisoning Nephrotoxicity Electrochemistry 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Antkowiak WZ, Gessner WP (1979) The structures of orellanine and orelline. Tetrahedron Lett 21: 1931–1934Google Scholar
  2. Cohen-Addad C, Richard J-M, Guitel JC (1987) Structure of orellanine-trifluoroacetic acid complex C10N2O6H8-CF3COOH: evidence of a very short O-H-O hydrogen bond. Acta Cryst C43: 504–507Google Scholar
  3. Grzymala S (1962) L'isolement de l'orellanine, poison duCortinarius orellanus Fries, et l'étude de ses effets anatomo-pathologiques. Bull Soc Mycol Fr 78: 394–404Google Scholar
  4. Homer RF, Mees GC, Tomlinson TE (1960) Mode of action of dipyridyl quaternary salts as herbicides. J Sci Food Agric 11: 309–315Google Scholar
  5. Klein G, Richard J-M, Satre M (1986) Effect of a mushroom toxin, orellanine, on the cellular slime moldDictyostelium discoideum and the bacteriumEscherichia coli. Microbiol Lett Fed Eur Microbiol Soc 33: 19–22Google Scholar
  6. Richard J-M (1987) Etude de l'orellanine, toxine deCortinarius orellanus Fries. Université Scientifique, Technologique et Médicale de Grenoble. UFR de Pharmacie. D Se Thesis no 4, pp 21–29Google Scholar
  7. Richard J-M, Taillandier G, Benoit-Guyod J-L (1985) A quantitative structure-activity relationship study on substituted pyridines as a contribution to the knowledge of the toxic effects of orellanine, a toxin from the mushroomCortinarius orellanus. Toxicon 23: 815–824Google Scholar
  8. Richard J-M, Ravanel P, Cantin D (1987) Phytotoxicity of orellanine, a mushroom toxin. Toxicon 25: 350–354Google Scholar
  9. Schumacher T, Hoiland K (1983) Mushroom poisoning caused by species of the genusCortinarius Fries. Arch Toxicol 53: 87–106Google Scholar
  10. Smith LL (1985) Paraquat toxicity. Philos Trans Roy Soc London B311: 647–657Google Scholar
  11. Tebbett IR, Caddy B (1984) Mushroom toxins of the genusCortinarius. Experientia 40: 441–446Google Scholar
  12. Tiecco M, Tingoli M, Testaferri L, Chianelli D, Wenkert E (1986) Total synthesis of orellanine, the lethal toxin ofCortinarius orellanus Fr. mushroom. Tetrahedron 42: 1475–1485Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Jean-Michel Richard
    • 1
  • Josette Louis
    • 3
  • Danielle Cantin
    • 2
  1. 1.Laboratoire de Chimie et ToxicologieUniversité J. Fourier, GrenobleMeylan CedexFrance
  2. 2.Laboratoire de Chimie Analytique, U. F. R. de PharmacieUniversité J. Fourier, GrenobleMeylan CedexFrance
  3. 3.Laboratoire d'Histologie, Embryologie et Cytogénétique, Faculté de MédecineUniversité J. Fourier, GrenobleMeylan CedexFrance

Personalised recommendations