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Archives of Toxicology

, Volume 62, Issue 2–3, pp 236–239 | Cite as

Transfer of benzo(a)pyrene into mouse embryos and fetuses

  • Diether Neubert
  • Stephanie Tapken
Short Communication

Abstract

The distribution of radioactive material within maternal and embryonic/fetal mouse tissue was studied over a period of 2 days following a single dose of14C-benzo (a)pyrene (B(a)P) orally on days 11, 12, 13 or 18 of pregnancy. B(a)P poorly penetrated into the embryo/fetus, and14C-radioactivity was found in embryonic tissues at concentrations one to two orders of magnitude lower than in maternal organs. If the compound was administered for 3 consecutive days at the same dose the expected cumulation was compensated for by an accelerated elimination of the substance, which is probably due to enzyme induction.

Keywords

Benzo(a)pyrene Placental transfer Mouse embryos 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Diether Neubert
    • 1
  • Stephanie Tapken
    • 1
  1. 1.Institut für Toxikologie und EmbryopharmakologieFreie Universität BerlinBerlin 33

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