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Associations between atopic diseases and the polymorphic systems ABO, kidd, inv and red cell acid phosphatase

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Summary

In 239 German patients with atopic conditions (atopic dermatitis, hay fever, allergic rhinitis, bronchial asthma, and acute urticaria) the phenotype and gene distribution of 15 genetic blood polymorphisms (ABO, MNSs, Rhesus, P, Kell, Duffy, Kidd, Hp, Gc, Gm, Inv, aP, PGM1, EsD, and 6-PGD) were analyzed and compared with those in 151 selected controls (individuals clinically free of allergic conditions and without allergy in the family history). The incidence of blood group antigens A and B was somewhat higher in patients than in controls. These observations are in accordance with the results of previous studies in other populations. In addition, our observation favor the hypothesis that there are also associations between the phenotypes Jk (a-b+), Inv(1) and red cell acid phosphatase aP a and aP AP on the one hand and atopic disposition on the other. The possible reasons for these associations are discussed.

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References

  1. Anand, S.: The relationship of ABO, MN, and rhesus blood groups to asthma. Indian J. Chest. Dis. Allied Sci.6, 74 (1964)

  2. Bender, K.: Immunglobuline. I. Genetik der Antikörperbildung. In: Humangenetik. Ein kurzes Handbuch in fünf Bänden, P. E. Becker, ed., Vol. I/3, pp 223–243. Stuttgart: Thieme 1975

  3. El-Mehairy, M. M., El-Tarabishi, N.: The correlation between ABO blood groups and allergic disorders. Ann. Allergy27, 366 (1966)

  4. Filsoufi, J.: Etude statistique des rapports entre les maladies allergiques et les goupes sanguins. Rev. Fr. Allergol.15, 115–117 (1975)

  5. Kareemullah, L., Taneja, V., Begum, S., Sarma, P. K. M., Baig, H. A.: Association of ABO blood groups and vitiligo. J. Med. Genet.14, 211–213 (1977)

  6. Khalil, L.: The ABO blood groups and disease in infants and children. Acta Paediatr. Scand.49, 76–80 (1960)

  7. Ksenofontov, Y. P.: Study of genetic markers in bronchial asthma and diabetes mellitus. Genetika8, 119–122 (1972)

  8. Lamerz, R., Fadeh-Moghadam, A.: Immunoglobulin E. Biochemische, immunologische Eigenschaften und klinische Bedeutung. Klin. Wochenschr.52, 1–17 (1974)

  9. Mano, K., Harada, S., Miyahara, H., Miyamoto, T., Horiuchi, Y.: The distribution of polymorphic traits in atopic asthmatic patients. Acta Allergol. (Kbh.)30, 80–88 (1975)

  10. Moniwa, H.: Statistical studies on the correlation between the ABO blood groups and some diseases. Tohoku J. Exp. Med.72, 275–280 (1960)

  11. Prokop, O., Göhler, W.: Die menschlichen Blutgruppen, 4. Aufl. Jena: Fischer 1976

  12. Rasmuson, M., Collinder, E., Henschen-Edman, A., Widström, G.: Allergic reaction patterns in relation to age, sex, season, eosinophilia and some genetic markers. Acta Allergol. (Kbh.)28, 365–400 (1973)

  13. Vega, A. R. de la, Cortés, J. G., Gallestey, J. B.: Genetic polymorphisms of ABO and Rh system in relation to bronchial asthma: preliminary report. Allergol. Immunopathol. (Madr.)4, 305–310 (1976)

  14. Woolf, B.: On estimating the relation between blood groups and disease. Ann. Hum. Genet.19, 251–253 (1955)

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Correspondence to H. Walter.

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Brachtel, R., Walter, H., Beck, W. et al. Associations between atopic diseases and the polymorphic systems ABO, kidd, inv and red cell acid phosphatase. Hum Genet 49, 337–348 (1979). https://doi.org/10.1007/BF00569354

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Keywords

  • Asthma
  • Dermatitis
  • Atopic Dermatitis
  • Rhinitis
  • Allergic Rhinitis