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Synthesis and properties of analogs of 5(4)-aminoimidazole-4(5)-carboxamide and purines. 11. Investigation of the structure and reactivity of imidazolethioamides

Abstract

The IR, UV, and PMR spectra of 5(4)-mercaptoimidazole-4(5)-carboxamide, 5(4)-hydroxyimldazole-4(5)-thiocarboxyamide, 5(4)-mercaptoimidazole-4(5)-thiocarboxamide, and the corresponding methyl derivatives were studied. It is shown that the mercaptoimidazoles obtained exist in the form of zwitterions in solution. The methylation of the mercapto- and hydroxyimidazoles with various methylating agents in solvents was investigated, and the reaction of the thioamides with hydrazine was carried out.

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See [1] for Communication 10.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 957–962, July, 1982.

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Bakulev, V.A., Mokrushin, V.S., Grishakov, A.N. et al. Synthesis and properties of analogs of 5(4)-aminoimidazole-4(5)-carboxamide and purines. 11. Investigation of the structure and reactivity of imidazolethioamides. Chem Heterocycl Compd 18, 731–736 (1982). https://doi.org/10.1007/BF00568953

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Keywords

  • Methyl
  • Organic Chemistry
  • Hydrazine
  • Purine
  • Zwitterion