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Studies on streptothricins VII. Determination of the ninhydrin-positive fragments of streptothricin antibiotics

Summary

1. A method for the quantitative analysis of the hydrolyzates of streptothricin antibiotics has been developed and has been used to determine the composition of representatives of the six types of this group of substances.

2. The empirical formulae previously established for the new antibiotics have been confirmed and a proposed structure of the six types of streptothricins is discussed.

3. On the basis of the results obtained, the hypothesis put forward that the empirical and structural formula of the antibiotic streptoline proposed by American workers is incorrect. A new empirical formula is proposed for this compound.

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References

  1. 1.

    P. D. Reshetov and A. S. Khokhlov, KhPS, 1, 42, 1965.

  2. 2.

    P. D. Reshetov, N. O. Blinov, and A. S. Khokhlov, Antibiotiki, 104, 1963.

  3. 3.

    H. R. Roberts, Anal Chem., 29, 1443, 1957.

  4. 4.

    S. M. Sibalic and N. V. Radej, Anal. Chem., 33, 1223, 1961.

  5. 5.

    I. M. Hais and K. Maček, Handbuch der Papierchromatographie, Jena 1958.

  6. 6.

    S. G. Waley and J. Watson, Biochem. J., 55, 328, 1953.

  7. 7.

    R. A. Clayton and F. M. Strong, Anal. Chem., 26, 1362, 1954.

  8. 8.

    E. E. van Tamelen et al., J. Am. Chem. Soc., 83, 4295, 1961.

  9. 9.

    S. Takemura, Chem. and Pharm. Bull., 8, 578, 1960.

  10. 10.

    D. R. Kominz, J. Chromatography, 9, 253, 1962.

  11. 11.

    D. H. Spackman, W. H. Stein, and S. Moore, Anal. Chem., 30, 1190, 1958.

  12. 12.

    U. F. Roubein, Dissertation Abstr., 22, 1390, 1961; C. A., 56, 7429, 1962.

  13. 13.

    H. Brockman and R. Cölln. Ber., 92, 114, 1959.

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Additional information

Khimiya Prirodnykh Soedinenii, Vol. 1, No. 2, pp. 117–122, 1965

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Reshetov, P.D., Egorov, T.A. & Khokhlov, A.S. Studies on streptothricins VII. Determination of the ninhydrin-positive fragments of streptothricin antibiotics. Chem Nat Compd 1, 91–95 (1965). https://doi.org/10.1007/BF00568732

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Keywords

  • Empirical Formula
  • Glucosamine
  • Ninhydrin
  • Aminosugar
  • Hexosamine