Hydrolytic stability of the ester bond in aminoacyl derivatives of N-acetylglucosamine, glucosamine, and N-acetylneuraminic acid
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The hydrolytic stability of the ester bond of O-aminoacyl derivatives of N-acetylglucosamine, glucosamine (base), and methyl N-acetylneuraminate has been studied at pH 1–8. It has been shown that the stability of the O-aminoacyl derivatives of N-acetylglucosamine is comparable with that of the corresponding glucose derivatives. The presence of a free amino group in glucosamine leads to a considerable labilization of the ester bond. The ester bond of the O-aminoacyl derivatives of methyl N-acetylneuraminate is characterized by a very high lability, and this must be taken into account in working with biopolymers.
KeywordsGlucosamine Ester Bond Amino Sugar Hydrolytic Stability Neuraminic Acid
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