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Synthesis of Z-L-Phe-L-His-L-Leu, a substrate of carboxycathepsin


It has been shown that in the synthesis of the peptide Z-L-Phe-L-His-L-Leu by various methods, the best results are obtained by extending the peptide chain from the C-end by the method using activated N-hydroxysuccinimide esters.

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Additional information

Institute of Biological and Medicinal Chemistry, Academy of Sciences of the USSR. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 637–642, September–October, 1975.

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Pozdnev, V.F., Dolinskaya, S.I., Uvarova, N.N. et al. Synthesis of Z-L-Phe-L-His-L-Leu, a substrate of carboxycathepsin. Chem Nat Compd 11, 666–669 (1975).

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  • Ethyl Acetate
  • Methyl Ester
  • DMFA
  • Hydantoin
  • Benzyloxy