Synthesis of the heptapeptide of the cyclopeptide moiety of polymixin B
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The synthesis of the heptapeptideNɛ-BOC-Nα-pelargonyl-L-lysyl-Nɛ-Z-L-lysyl-D-phenylalanyl-L-leucyl-Nɛ-Z-L-lysyl-Nɛ-Z-L-lysyl-L-threonine, a linear analog of the cyclopeptide part of the antibiotic polymixin B, has been effected (yield 63%). The possibility of using this method for the synthesis of peptides on a polymer support without protecting the hydroxyl group of threonine has been shown.
KeywordsPelargonic Acid Triethylamine Hydrochloride Diaminobutyric Acid Weakly Acid Reaction Attached Amino Acid
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