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Amino acid and peptide derivatives of the indole series

III. Synthesis and properties of analogs of α-methyltryptamine

Summary

1. A method for obtaining amino acid and peptide derivatives of α-methyltryptamine have been described.

2. In respect of their biological activity, the closest to Indopan are glycyl-α-methyltryptamine and L-α-glutamyl-α-methyltryptamine, which, at the same time, possess a weaker action on the peripheral adrenoreactive system.

3. When amino acid residues are introduced into the molecule of α-methyltryptamine, not only does the degree of biological activity of the compound change but, in some cases, new biological properties actually appear.

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Khimiya Prirodnykh Soedinenii, Vol. 3, No. 2, pp. 108–116, 1967

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Neklyudov, A.D., Shchukina, L.A., Suvorov, N.N. et al. Amino acid and peptide derivatives of the indole series. Chem Nat Compd 3, 90–96 (1967). https://doi.org/10.1007/BF00567176

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Keywords

  • Tyramine
  • Hydrazine Hydrate
  • Tryptamine
  • Amino Acid Derivative
  • Phthalic Anhydride