Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Pilot study of the effect of terodiline chloride (Bicor®) in obstructive pulmonary disease


Terodiline chloride, 150 mg daily, was administered to 10 patients with obstructive pulmonary disease, and pulmonary function tests were performed before and during two weeks of therapy. Serious side effects of anticholinergic type developed in two patients who stopped treatment. Two patients were excluded from the trial for other reasons. The remaining six patients showed signs of bronchodilation. Owing to the high incidence of side effects, treatment with more than 75 mg terodiline chloride per day is impracticable.

This is a preview of subscription content, log in to check access.


  1. Iravani, J.: Antagonismus zwischen Terodilin (Bicor) und Acetylcholin an der Bronchialmuskulatur der Ratte. In press (1974)

  2. Lecerof, H., Malmborg, R.O.: Central hemodynamic effects of terodiline in patients with coronary heart disease. Acta med. scand.186 231–234 (1969)

  3. Nisell, J.: Personal communication

  4. Pepine, C. J., Wiener, L.: Relationship of anginal symptoms to lung mechanics during myocardial ischemia. Circulation46 863–869 (1972)

  5. Ulmer, W.T.: Personal communication

  6. Vessman, J., Strömberg, S.: Determination of terodiline (Bicor®) in serum by gas chromatography and electron capture detection of benzophenone formed by chromic acid oxidation. Acta pharm. suec.6 508–518 (1969)

  7. Wibell, L.: Some aspects of the treatment of angina pectoris with presentation of terodiline, a new drug. Opusc. med. (Stockh.)13 78 (1968 a)

  8. Wibell, L.: Terodiline in angina pectoris — a controlled study of a new drug. Acta Soc. Med. upsalien.73 75 (1968 b)

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Castenfors, H., Hedenstierna, G. & Glenne, P.-. Pilot study of the effect of terodiline chloride (Bicor®) in obstructive pulmonary disease. Eur J Clin Pharmacol 8, 197–200 (1975).

Download citation

Key words

  • Terodiline
  • obstructive pulmonary disease
  • lung function
  • heart rate
  • side effects
  • bronchodilation