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Synthesis of analogs of valinomycin and enniatine B containing charged, spin-labeled, or fluorescent groups

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1. The synthesis of six functional derivatives of valinomycin and enniatine B containing amine or carboxy groups in the side chain has been effected.

2. Four analogs of valinomycin and enniatine B containing spin-labeled or fluorescent groups have been obtained.

3. The antimicrobial activity of the compounds mentioned and also of the intermediate cyclodepsipeptides obtained during their synthesis has been studied.

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Additional information

M. M. Shemyakin Institute of the Chemistry of Natural Compounds of the Academy of Sciences of the USSR. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 346–358 May–June, 1974.

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Ivanov, V.T., Sumskaya, L.V., Mikhaleva, I.I. et al. Synthesis of analogs of valinomycin and enniatine B containing charged, spin-labeled, or fluorescent groups. Chem Nat Compd 10, 350–358 (1974). https://doi.org/10.1007/BF00563892

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  • Valinomycin
  • Thionyl Chloride
  • Depsipeptide
  • Dansyl Chloride
  • Phthaloyl