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Double-blind comparison of the analgesic response to oral ciramadol (WY-15.705) and pentazocine in post-operative pain

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The efficacy and safety of oral ciramadol, a synthetic partial agonist-antagonist analgesic, in rapid control of postoperative pain was compared with oral pentazocine in a double blind study in 46 patients. Ciramadol 20 mg and 60 mg and pentazocine 50 mg had a rapid analgesic effect, peaking within one hour. Although a similar pattern of activity was observed for ciramadol 20 mg and pentazocine 50 mg, ciramadol 60 mg provided significantly better and longer lasting pain relief (P<0.02). Side effects included sedation and sweating, which occurred with a similar frequency in the various treatment groups. Oral ciramadol appears to be a safe and highly effective analgesic.

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Camu, F. Double-blind comparison of the analgesic response to oral ciramadol (WY-15.705) and pentazocine in post-operative pain. Eur J Clin Pharmacol 19, 259–262 (1981). https://doi.org/10.1007/BF00562802

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Key words

  • analgesia
  • ciramadol
  • pentazocine
  • post-operative pain
  • double-blind trial