European Journal of Clinical Pharmacology

, Volume 4, Issue 2, pp 107–114 | Cite as

Acute effects of clonidine on central and peripheral haemodynamics and plasma renin activity

  • J. Brod
  • L. Horbach
  • H. Just
  • J. Rosenthal
  • R. Nicolescu


After the intravenous administration of clonidine normo- and hypertensive patients were studied by measurement of central, peripheral and renal hemodynamics, and plasma renin activity. The patients were examined either at rest, or while supine after tilting to 30° for 10 min. In most patients 300 µg of clonidine lowered both the blood and pulse pressures, heart rate, stroke volume and cardiac index, as well as the central venous pressure. In general the peripheral vascular resistance did not change, although it fell in some hypertensive patients. Renal vascular resistance diminished and renal blood flow and glomerular filtration rate sometimes rose, but more frequently remained unchanged. — The results suggest a centrally mediated action of clonidine, possibly on the sympathetic system as they can be interpreted as evidence of inhibition of sympathetic responses. The failure of the peripheral renin level to rise supports this hypothesis.

Key words

Clonidine circulation renin symphatetic nerves haemodynamics 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • J. Brod
    • 1
    • 5
  • L. Horbach
    • 2
  • H. Just
    • 3
  • J. Rosenthal
    • 4
  • R. Nicolescu
    • 3
  1. 1.First Medical ClinicMainzGermany
  2. 2.Institute of Statistics and DocumentationMainzGermany
  3. 3.Division of CardiologySecond Medical ClinicMainzGermany
  4. 4.University HospitalBostonUSA
  5. 5.Department of NephrologyMedizinische HochschuleHannoverGermany

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