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European Journal of Clinical Pharmacology

, Volume 4, Issue 2, pp 107–114 | Cite as

Acute effects of clonidine on central and peripheral haemodynamics and plasma renin activity

  • J. Brod
  • L. Horbach
  • H. Just
  • J. Rosenthal
  • R. Nicolescu
Originals

Summary

After the intravenous administration of clonidine normo- and hypertensive patients were studied by measurement of central, peripheral and renal hemodynamics, and plasma renin activity. The patients were examined either at rest, or while supine after tilting to 30° for 10 min. In most patients 300 µg of clonidine lowered both the blood and pulse pressures, heart rate, stroke volume and cardiac index, as well as the central venous pressure. In general the peripheral vascular resistance did not change, although it fell in some hypertensive patients. Renal vascular resistance diminished and renal blood flow and glomerular filtration rate sometimes rose, but more frequently remained unchanged. — The results suggest a centrally mediated action of clonidine, possibly on the sympathetic system as they can be interpreted as evidence of inhibition of sympathetic responses. The failure of the peripheral renin level to rise supports this hypothesis.

Key words

Clonidine circulation renin symphatetic nerves haemodynamics 

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References

  1. 1.
    Graubner, W., Wolf, M.: Kritische Betrachtungen zum Wirkungsmechanismus des 2-(2,6-Dichlorphenylamino)-2-imidazolin-hydrochlorid. Arzneimittel-Forsch.16, 1055–1058 (1966).Google Scholar
  2. 2.
    Hoefke, W., Kobinger, W.: Pharmakologische Untersuchungen des 2-(2,6-Dichlorophenylamino)-2-imidazoline hydrochlorids, einer neuen antihypertensiven Substanz. Arzneimittel-Forsch.16, 1038–1050 (1966).Google Scholar
  3. 3.
    Kobinger, W.: Über den Wirkungsmechanismus einer neuen antihypertensiven Substanz mit Imidazolin-Struktur. Arch. Pharmakol. exp. Path.258, 48–58 (1967).Google Scholar
  4. 4.
    Brod, J.: Haemodynamic basis of acute pressor reactions and hypertension. Brit. Heart J.25, 227–245 (1963).Google Scholar
  5. 5.
    Bock, K. D., Heimsoth, V., Merguet, P., Schoenermark, J.: Klinische und klinisch-experimentelle Untersuchungen mit einer neuen blutdrucksenkenden Substanz: Dichlorphenylaminoimidazolin. Dtsch. med. Wschr.91, 1761–1770 (1966).Google Scholar
  6. 6.
    Krochsick, K., Fritsche, H.: Die Wirkung eines Imidazolin-Derivates auf den arteriellen Blutdruck, die Haemodynamik und die Ventilation. Arzneimittel-Forsch.16, 1154–1160 (1966).Google Scholar
  7. 7.
    Vorburger, C., Buetikofer, E., Weiss, S., Diacon, C.: Die akute Wirkung von ST-155, einem neuen Hypotensivum, auf die kardiale und renale Haemodynamik. Helv. med. Acta34 (Suppl. 47): 133–134 (1967).Google Scholar
  8. 8.
    Villalpando, J., Flores, A., Exaire, E., Mireles, M., Serrano, P.: Estudio clinico hemodinamico de un nuevo antihipertensivo: Catapresan (ST-155). Arch. Inst. Cardiol. Méx.37, 689–699 (1967).Google Scholar
  9. 9.
    Pozene, H.: Das Verhalten haemodynamischer Größen von Hypertonikern unter Therapie mit Dichlorphenylamino-Imidazolinhydrochlorid. Wien. klin. Wschr.81, 187–192 (1969).Google Scholar
  10. 10.
    Onesti, G., Schwartz, A. B., Kim, K. E., Swartz, C., Brest, A. N.: Pharmacodynamic effects of a new antihypertensive drug, Catapres (ST-155). Circulation39, 219–228 (1969).Google Scholar
  11. 11.
    Schneider, K. W., Gattenlöhner, W., Müller, W.: Die haemodynamischen Veränderungen nach Dichlorphenyl-amino-imidazolinhydrochlorid im akuten und chronischen Versuch. Verh. dtsch. Ges. inn. Med.73, 611–616 (1967).Google Scholar
  12. 12.
    Villalpando, J., Exaire, E., Serrano, P.: Modificaciones en la hemodinamica renal y las catecholaminas con un nuevo antihipertensivo. Sem. med. Mex.56, 105–110 (1968).Google Scholar
  13. 13.
    Brest, A. N.: Pharmacodynamic effects of Catapres. Intern. Symp. “Catapres in Hypertension”, London, p. 71–77. London: Butterworths 1969.Google Scholar
  14. 14.
    Ludwig, Hj.: Der Einfluß der Langzeitbehandlung mit 2-(2,6-Dichlorphenylamino)-2-imidazolin · HCl auf die Nierenhaemodynamik beim arteriellen Hochdruck. Arzneimittel-Forsch.18, 600–604 (1968).Google Scholar
  15. 15.
    Reubi, F. C., Vorburger, C., Buetikofer, E.: A comparison of the short-term and long-term haemodynamic effects of antihypertensive drug therapy. Intern. Symp. “Catapres in Hypertension”, London, p. 113–125. London: Butterworths 1969.Google Scholar
  16. 16.
    Merguet, P., Heimsoth, V., Murata, T., Bock, K. D.: Study on the circulatory effects of 2-(2,6-dichlorphenylamino)-2-imidazolinehydrochloride in man. Pharmacol. Clin.1, 30–37 (1968).Google Scholar
  17. 17.
    Schmitt, H., Schmitt, H.: Localization of the hypotensive effect of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (St 155, Catapresan) in the medulla oblongata. Europ. J. Pharmacol.6, 8–12 (1969).Google Scholar
  18. 18.
    Sherman, G. F., Greca, G. I., Woods, R. J., Buckley, J. R.: Evidence for a central hypotensive mechanism for 2-(2,6-dichlorophenylamino)-2-imidazoline (Catapresan, St 155). Europ. J. Pharmacol.2, 326–328 (1968).Google Scholar
  19. 19.
    Sattler, R. W., Van Zwieten, P. A.: Acute hypotensive action of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (St 155) after infusion into the cat's vertebral artery. Europ. J. Pharmacol.2, 9–13 (1967).Google Scholar
  20. 20.
    Constantine, J. W., McShane, W. K.: Analysis of the cardiovascular effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (Catapres). Europ. J. Pharmacol.4, 109–123 (1968).Google Scholar
  21. 21.
    Boucher, R., Veyrat, R., de Champlain, J., Genest, J.: New procedures for measurement of human plasma angiotensin and renin activity levels. Canad. med. Ass. J.90, 194–201 (1964).Google Scholar
  22. 22.
    Boucher, R., Genest, J.: Improvement in methodology for measurement of peripheral renin activity. Canad. J. Physiol. and Pharmacol.44, 181–182 (1966).Google Scholar
  23. 23.
    Just, H., Brod, J., Horbach, L., Meyer, Ph., Nicolescu, R. F., Rosenthal, J., Wolff, H. P.: Changes of hemodynamics and renin activity during mild orthostasis in man. No yet published.Google Scholar
  24. 24.
    Sternberg, J., Hohnberg, S., Naets, E., Varnauskas, E.: The hemodynamic effects of Catapresan. Central circulation at rest, circulation at rest and during exercise. “Hochdruck-Therapie” — Symp. Ulm, 1967, Berlin: Springer.Google Scholar
  25. 25.
    Zaimis, E.: On the pharmacology of Catapres (St 155). Intern. Symp. “Catapres in Hypertension”, p. 9–22. London: Butterworths, 1969.Google Scholar
  26. 26.
    Oparil, S., Vassaux, C., Sanders, C. A., Haber, E.: “Role of renin in acute postural homoiostasis”. Circulation41, 89–95 (1970).Google Scholar
  27. 27.
    Hoekfelt, B., Hedeland, H., Dymling, J.-F.: “The influence of catapres on Catecholamines, renin and aldosterone in man.” Intern. Symp. “Catapres in Hypertension”, London, p. 85–99. London: Butterworths 1969.Google Scholar
  28. 28.
    Brod, J., Fencl, V., Hejl, Z., Jirka, J., Ulrych, M.: (1972). Basic haemodynamic pattern of reno-parenchymatous hypertension. The Kidney1. (In press.)Google Scholar

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • J. Brod
    • 1
    • 5
  • L. Horbach
    • 2
  • H. Just
    • 3
  • J. Rosenthal
    • 4
  • R. Nicolescu
    • 3
  1. 1.First Medical ClinicMainzGermany
  2. 2.Institute of Statistics and DocumentationMainzGermany
  3. 3.Division of CardiologySecond Medical ClinicMainzGermany
  4. 4.University HospitalBostonUSA
  5. 5.Department of NephrologyMedizinische HochschuleHannoverGermany

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