Late plasma half-lives of dextro and racemic propranolol were measured in seven adult male subjects after 100 mg taken orally. Mean plasma half-lives of 2.38±0.43 and 2.93±0.63 h were obtained for dextro and racemic preparations respectively. In five of these subjects plasma half-lives after 50 mg dextro and laevo isomers were 2.02±0.53 and 3.20±0.42 h. No difference was found in the rates of absorption of the two isomers It is concluded that these results reflect either differences in distribution or a slower rate of metabolism of the laevo isomer.
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Furner, R.L., McCarthy, J.S., Stitzel, R.E., Anders, M.W.: Stereoselective metabolism of the enantiomers of hexobarbital. J. Pharmacol. exp. Ther.169, 153–158 (1969).
Keberle, H., Hoffman, K., Bernhard, K.: The metabolism of glutethimide (Doriden). Experientia (Basel)18, 105–111 (1962).
Palmer, K.H., Fowler, M.S., Wall, M.E., Rhodes, L.S., Waddell, W.J., Baggett, B.: The metabolism of R(+) and RS pentobarbital. J. Pharmacol. exp. Ther.170, 355–363 (1969).
—— —— —— Metabolism of optically active barbiturate II S(−) pentobarbital. J. Pharmacol. exp. Ther.175, 38–41 (1970).
Paterson, J.W., Conolly, M.E., Dollery, C.T., Hayes, A., Cooper, R.G.: The pharmacodynamics and metabolism of propranolol in man. Europ. J. clin. Pharmacol.2, 127–133 (1970).
Shand, D.G., Nuckolls, E.M., Oates, J.A.: Plasma propranolol levels in adults. Clin. Pharmacol. Ther.11, 112–120 (1970).
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George, C.F., Fenyvesi, T., Conolly, M.E. et al. Pharmacokinetics of dextro-, leavo- and racemic propranolol in man. Eur J Clin Pharmacol 4, 74–76 (1972). https://doi.org/10.1007/BF00562500
- optical isomers