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Pharmacokinetics of dextro-, leavo- and racemic propranolol in man

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Late plasma half-lives of dextro and racemic propranolol were measured in seven adult male subjects after 100 mg taken orally. Mean plasma half-lives of 2.38±0.43 and 2.93±0.63 h were obtained for dextro and racemic preparations respectively. In five of these subjects plasma half-lives after 50 mg dextro and laevo isomers were 2.02±0.53 and 3.20±0.42 h. No difference was found in the rates of absorption of the two isomers It is concluded that these results reflect either differences in distribution or a slower rate of metabolism of the laevo isomer.

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George, C.F., Fenyvesi, T., Conolly, M.E. et al. Pharmacokinetics of dextro-, leavo- and racemic propranolol in man. Eur J Clin Pharmacol 4, 74–76 (1972). https://doi.org/10.1007/BF00562500

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Key words

  • Propranolol
  • optical isomers