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Pharmacokinetics of dextro-, leavo- and racemic propranolol in man

  • C. F. George
  • T. Fenyvesi
  • M. E. Conolly
  • C. T. Dollery
Originals

Summary

Late plasma half-lives of dextro and racemic propranolol were measured in seven adult male subjects after 100 mg taken orally. Mean plasma half-lives of 2.38±0.43 and 2.93±0.63 h were obtained for dextro and racemic preparations respectively. In five of these subjects plasma half-lives after 50 mg dextro and laevo isomers were 2.02±0.53 and 3.20±0.42 h. No difference was found in the rates of absorption of the two isomers It is concluded that these results reflect either differences in distribution or a slower rate of metabolism of the laevo isomer.

Key words

Propranolol optical isomers 

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References

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • C. F. George
    • 1
  • T. Fenyvesi
    • 1
  • M. E. Conolly
    • 1
  • C. T. Dollery
    • 1
  1. 1.M.R.C. Clinical Pharmacology Research GroupRoyal Postgraduate Medical SchoolLondonEngland

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