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Central effects of theβ-adrenergic blocking agent acebutolol

A quantitative EEG study using normalised slope descriptors


The effects of acute intravenous injection of acebutolol 25 mg on the EEG were investigated in 5 normal subjects. On-line EEG analysis was carried out by a special purpose mini-computer using normalised slope descriptors (Hjorth parameters). No significant changes were found apart from those due to drowsiness in 2 subjects, although minute to minute ECG frequency was significantly lowered (p=0.031). The EEG, which is considered to be a sensitive tool, failed to show any conclusive evidence of any central action of the drug. The effects of beta-adrenergic blockers on the CNS are not yet fully understood.

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  1. Baché, S.: The effects of beta-adrenergic receptor blocking agents on animal central nervous systems. Comparison of acebutolol with practolol and propranolol. Clin. Trials J.3, 51–53 (1974)

  2. Granville-Grossmann, K.L., Turner, P.: The effect of propranolol anxiety. Lancet1966 I, 788–790

  3. Hjorth, B.: EEG analysis based on time domain properties. EEG clin. Neurophysiol.29, 306–310 (1970)

  4. Lader, M.H., Tyrer, P.J.: Central and peripheral effects of propranolol and sotalol in normal human subjects. Brit. J. Pharmacol.45, 557–560 (1972)

  5. Leszkovsky, G., Tadros, L.: Some effects of propranolol on the central nervous system. J. Pharm. Pharmacol.17, 518–520 (1965)

  6. Matejcek, M., Devos, J.E.: Selected methods of quantitative EEG analysis and their applications in psychotropic research. In Quantitative Analytic Studies in Epilepsy. (ed. P. Kallaway and I. Petersen). New York: Raven Press 1976

  7. Murmann, W., Almirante, L., Saccani-Guelfi, M.: Central nervous system effects of four β-adrenergic receptor blocking drugs. J. Pharm. Pharmacol.18, 317–318 (1966)

  8. Waal, H.J.: Propranolol — induced depression. Brit. med. J. 1967/2, 50

  9. Winkler, G.F., Young, R.R.: Efficacy of chronic propranolol therapy in action tremor of the familial, senile or essential varieties. New Engl. J. Med.83, 234–235 (1974)

  10. Zilam, D.H., Sellers, E.M.: The effect of propranolol on normal physiologic tremors. EEG clin. Neurophysiol.41, 310–313 (1976)

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Kayed, K., Godtlibsen, O.B. Central effects of theβ-adrenergic blocking agent acebutolol. Eur J Clin Pharmacol 12, 327–331 (1977).

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  • β-adrenergic blocker
  • acebutolol
  • central actions
  • EEG
  • automatic analysis