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The influence of metabolites of digoxin and digitoxin on the86Rb-uptake assay

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The influence of metabolites of digoxin and digitoxin on86Rb-uptake by red blood cells was studied. All the metabolites tested were inhibitors of86Rb-uptake and could influence the results obtained by this assay method for plasma levels of digoxin and digitoxin. Their inhibitory activity on red cells was related to their cardioactivity.

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Aided by a grant from the FWGO, Belgium.

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Kaufman, J.M., Belpaire, F.M. The influence of metabolites of digoxin and digitoxin on the86Rb-uptake assay. Eur J Clin Pharmacol 6, 54–56 (1973). https://doi.org/10.1007/BF00561801

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Key words

  • 86Rb-uptake method
  • digoxin metabolites
  • digitoxin metabolites
  • metabolites of cardiac glycosides