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Placental transfer of atropine at the end of pregnancy

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In a first study, 28 pregnant women received a fast intravenous injection of atropine sulphate 12.5 µg/kg, as in a classical atropine test. Fetal tachycardia resulted. The maternal venous blood concentration of atropine, determined by bioassay on guinea pig ileum, decreased rapidly in the first 3–5 min and very slowly thereafter

In a second study, 45 women in labour received the same dose i. v., and at birth atropine was measured both in maternal and cord blood. Placental transfer of atropine had occurred in every case and was highly variable, depending on the maternal blood concentration of the drug. This suggests that the atropine test is not mainly dependent on placental function.

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  1. Barrier, G., Olive, G., Onnen, I., Daille-Dupont, Merceron, L.: La pharmacocinétique de l'atropine chez la femme enceinte et le foetus en fin de grossesse. Anesth. Analg. Réanimat.33, 795–800 (1976)

  2. Brunel, G., Winkler, J. L.: The value of the atropine test in therapeutic orientation during foeto-placental insuffisiency. Am. J. Obstet. Gynecol.88, 150–175 (1962)

  3. Burn, J. M.: Practical physiology, pp. 1–22, Oxford: Blackwell Scientific, 1952

  4. Goldstein, A., Aronow, L., M. Kalman, S.: Principles of drug action, pp. 198–202, New York: John Wiley, 1974

  5. Hellman, L. M., Johnson, H. L., Tolles, W. E., Jones, E. H.: Some factors acting on the fetal heart rate. Am. J. Obstet. Gynecol.82, 1055–1063 (1961)

  6. Hellman, L.M., Morton, G.W., Wallach, E.D., Tolles, W.E., Fillisti, L.P.: An analysis of the atropine test for placental transfer in 28 normal gravidas. Am. J. Obstet. Gynecol.87, 650–659 (1963)

  7. Hon, E. H., Bradfield, A. H., Hess, O. W.: The elektronic evaluation of the fetal heart rate. The vagal factor in fetal bradycardia. Am. J. Obstet. Gynecol.82, 291–300 (1961)

  8. John, A.H.: Placental transfer of atropine and the effect on fetal heart rate. Br. J. Anesth.37, pp. 57–60 (1965)

  9. Kalser, J. C., McLain, P. L.: Atropine metabolism in man. Clin. Pharmacol. Ther.11, 214–22 (1970)

  10. Kivalo, I., Saarikoski, S.: Quantitative measurements of placental transfer and distribution of radioactive atropine in human fetus. Ann. Chir. Gynaecol. Fenn.59, 80–84 (1970)

  11. Morton, H. J. V., Thomas, E. T.: Effect of atropine on the heart rate. Lancet 1958 II, 1313–1315

  12. Onnen, I.: Contribution à l'étude pharmacocinétique de l'atropine injectée par voie intraveineuse chez la femme enceinte en fin de grossesse et dans le sang du cordon. Thèse de Médecine, CHU Lariboisière-Saint-Louis, Paris 7 (Oct. 1974)

  13. Root, E., Eichner, E.: Blood secobarbital levels and their clinical correlates in mothers and newborn infants. Am. J. Obstet. Gynecol.81, 948–956 (1961)

  14. Schifferli, P.Y., Caldeyro-Barcia, R.: Effects of atropine and beta adrenergic drugs on the heart rate of the human fetus. Fetal Pharmacology. L. Boreus (Ed.) pp. 259–270, New York: Raven 1973

  15. Soiva, K., Sahli, A.: Phonocardiographic studies of the fetal heart rate. Ann. Chir. Gynaecol. Fenn.48, 5237–5298 (1969)

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Onnen, I., Barrier, G., d'Athis, P. et al. Placental transfer of atropine at the end of pregnancy. Eur J Clin Pharmacol 15, 443–446 (1979). https://doi.org/10.1007/BF00561745

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Key words

  • atropine
  • placental transfer
  • fetal heart rate
  • maternal blood level
  • fetal blood level