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Is captopril effective in controlling blood pressure when administered once daily? An assessment using 24-h ambulatory blood pressure monitoring


Twelve patients with essential hypertension receiving captopril monotherapy or captopril in conjunction with a diuretic had their 24-h blood pressure profiles monitored using an automatic, non-invasive ambulatory method. The study examined the efficacy of once a day versus twice a day administration of the ACE inhibitor in controlling blood pressure.

Six untreated subjects with borderline hypertension were also studied using the same monitoring equipment and with the same frequency, to act as controls because of the possibility of repeated use of the device causing a ‘familiarisation’ effect.

The results obtained indicated that if anything, the once daily dosing produced marginally better blood pressure values. The amplitude of the diurnal blood pressure variation was reduced on a ‘second-wearing’ of the monitoring equipment suggesting some degree of familiarisation with the apparatus.

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  1. 1.

    Baumgart P, Tenschert W, Vetter H (1986) Efficacy of low dose captopril once daily in diuretic resistant hypertension. Postgrad Med J 62 [Suppl 1]: 127–130

  2. 2.

    Gaudemaris R De, Battistella P, Siche JP, Debru JL, Blatier JF, Mallion JM (1986) Comparative study of the efficacy of captopril at a single daily dose of 100 mg and at a twice daily dose of 50 mg by measuring ambulatory pressure over 24 hours. Postgrad Med J 62 [Suppl 1]: 97–100

  3. 3.

    Fogari R, Zoppi A, Corradi L, Poletti L, Tettamanti F, Botta GF (1986) Hypotensive effect of once-daily administration of captopril. Curr Therap Res 40: 500–508

  4. 4.

    Garanin G (1986) A comparison of once-daily antihypertensive therapy with captopril and enalapril. Curr Therap Res 40: 567–575

  5. 5.

    Rodriguez FJ, Gil V, Beneyto MDC, Lopez-Vidriero E (1986) Effects of captopril once daily on blood pressure and angiotensin converting enzyme in hypertensive patients. Postgrad Med J 62 [Suppl 1]: 94–96

  6. 6.

    Halberg F (1969) Chronobiology. Annu Rev Physiol 31: 675–725

  7. 7.

    Harbert GM, Coiner IM, Turner SM, Nuzhet OA (1981) Biorhythms of the nonpregnant human uterus. J Reprod Biol 26: 493–498

  8. 8.

    Cugini P, Girelli I, Felici W, Latini M, Mechelli A, Tucciarone L (1986) Circadian rhythms of arterial pressure, heart rate, respiratory rate and body temperature in childhood. A cosinor analysis of the works of Imperato and Landucci (1948–1949). Minerva Pediatr 38: 537–543

  9. 9.

    Ohman KP, Kagedal B, Larsson R, Karlberg BE (1985) Pharmacokinetics of captopril and its effects on blood pressure during acute and chronic administration and in relation to food intake. J Cardiovasc Pharmacol 7: S20-S24

  10. 10.

    Dzau VJ (1987) Implications of local angiotensin production in cardiovascular physiology and pharmacology. Am J Cardiol 59: 59A-65A

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Frewin, D.B., Buik, C. & Rennie, G. Is captopril effective in controlling blood pressure when administered once daily? An assessment using 24-h ambulatory blood pressure monitoring. Eur J Clin Pharmacol 36, 11–15 (1989).

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Key words

  • hypertension
  • captopril
  • once-daily administration